Unconventional T cell targets for cancer immunotherapy

DI Godfrey, J Le Nours, DM Andrews, AP Uldrich… - Immunity, 2018 - cell.com
Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T
cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility …

Targeting natural killer cells and natural killer T cells in cancer

E Vivier, S Ugolini, D Blaise, C Chabannon… - Nature Reviews …, 2012 - nature.com
Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share
some phenotypical and functional similarities. Both cell types can rapidly respond to the …

The role of natural killer T cells in cancer—a phenotypical and functional approach

D Krijgsman, M Hokland, PJK Kuppen - Frontiers in immunology, 2018 - frontiersin.org
Natural killer T (NKT) cells are a subset of CD1d-restricted T cells at the interface between
the innate and adaptive immune system. NKT cells can be subdivided into functional …

Natural killer T cells in cancer immunotherapy

S Nair, MV Dhodapkar - Frontiers in immunology, 2017 - frontiersin.org
Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid
antigens. Following stimulation, NKT cells lead to downstream activation of both innate and …

Immune therapy for cancer

M Dougan, G Dranoff - Annual review of immunology, 2009 - annualreviews.org
Over the past decade, immune therapy has become a standard treatment for a variety of
cancers. Monoclonal antibodies, immune adjuvants, and vaccines against oncogenic …

Going both ways: immune regulation via CD1d-dependent NKT cells

DI Godfrey, M Kronenberg - The Journal of clinical investigation, 2004 - jci.org
NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation
of immune responses associated with a broad range of diseases, including autoimmunity …

Toward an understanding of NKT cell biology: progress and paradoxes

M Kronenberg - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract Natural killer T (NKT) cells constitute a conserved T cell sublineage with unique
properties, including reactivity for a synthetic glycolipid presented by CD1d, expression of an …

MAIT cells: new guardians of the liver

A Kurioka, LJ Walker, P Klenerman… - Clinical & translational …, 2016 - Wiley Online Library
The liver is an important immunological organ that remains sterile and tolerogenic in
homeostasis, despite continual exposure to non‐self food and microbial‐derived products …

Cancer immunotherapy: a treatment for the masses

JN Blattman, PD Greenberg - Science, 2004 - science.org
Cancer immunotherapy attempts to harness the exquisite power and specificity of the
immune system for the treatment of malignancy. Although cancer cells are less …

Presumed guilty: natural killer T cell defects and human disease

SP Berzins, MJ Smyth, AG Baxter - Nature Reviews Immunology, 2011 - nature.com
Natural killer T (NKT) cells are important regulatory lymphocytes that have been shown in
mouse studies, to have a crucial role in promoting immunity to tumours, bacteria and viruses …