[HTML][HTML] The lymphatic vasculature in the 21st century: novel functional roles in homeostasis and disease
Mammals have two specialized vascular circulatory systems: the blood vasculature and the
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …
lymphatic vasculature. The lymphatic vasculature is a unidirectional conduit that returns …
[HTML][HTML] Immune responses to injury and their links to eye disease
MANN Stepp, ASUE Menko - Translational Research, 2021 - Elsevier
The eye is regarded as an immune privileged site. Since the presence of a vasculature
would impair vision, the vasculature of the eye is located outside of the central light path. As …
would impair vision, the vasculature of the eye is located outside of the central light path. As …
Cell volume change through water efflux impacts cell stiffness and stem cell fate
Cells alter their mechanical properties in response to their local microenvironment; this plays
a role in determining cell function and can even influence stem cell fate. Here, we identify a …
a role in determining cell function and can even influence stem cell fate. Here, we identify a …
Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis
Wound healing is one of the most complex biological processes to occur in life. Repair of
tissue following injury involves dynamic interactions between multiple cell types, growth …
tissue following injury involves dynamic interactions between multiple cell types, growth …
Rho kinase inhibitors as a novel treatment for glaucoma and ocular hypertension
In an elegant example of bench-to-bedside research, a hypothesis that cells in the outflow
pathway actively regulate conventional outflow resistance was proposed in the 1990s and …
pathway actively regulate conventional outflow resistance was proposed in the 1990s and …
[HTML][HTML] Normal and glaucomatous outflow regulation
Glaucoma remains only partially understood, particularly at the level of intraocular pressure
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …
(IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal inner wall endothelium …
The vital role for nitric oxide in intraocular pressure homeostasis
Catalyzed by endothelial nitric oxide (NO) synthase (eNOS) activity, NO is a gaseous
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …
signaling molecule maintaining endothelial and cardiovascular homeostasis. Principally, NO …
The aqueous humor outflow pathways in glaucoma: A unifying concept of disease mechanisms and causative treatment
Intraocular pressure (IOP) is the critical risk factor for glaucoma, a neurodegenerative
disease and frequent cause of blindness worldwide. As of today, all effective strategies to …
disease and frequent cause of blindness worldwide. As of today, all effective strategies to …
Major review: Molecular genetics of primary open-angle glaucoma
Glaucoma is a leading cause of irreversible blindness worldwide. Primary open-angle
glaucoma (POAG), the most common type, is a complex inherited disorder that is …
glaucoma (POAG), the most common type, is a complex inherited disorder that is …
Trabecular meshwork stiffness in glaucoma
Alterations in stiffness of the trabecular meshwork (TM) may play an important role in primary
open-angle glaucoma (POAG), the second leading cause of blindness. Specifically, certain …
open-angle glaucoma (POAG), the second leading cause of blindness. Specifically, certain …