Abstract Phosphatidylinositol 3-kinase (PI3K)/AKT pathway regulates cell growth,
proliferation, survival, mobility and invasion. Mitogen-activated protein kinase …

Triple-negative breast cancers (TNBCs) constitute a heterogeneous subtype of breast
cancers that have a poor clinical outcome. Although no approved targeted therapy is …

Background The conversion from estrogen-dependent to estrogen-independent state of ER+
breast cancer cells is the key step to promote resistance to endocrine therapies. Although …

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, but
an effective targeted therapy has not been well-established so far. Considering the lack of …

Excess body weight is frequently associated with low-grade inflammation. Evidence
indicates a relationship between obesity and cancer, as well as with other diseases, such as …

Background Resistance to standard chemotherapy in metastatic triple-negative breast
cancer (mTNBC) is associated with upregulation of the mitogen-activated protein kinase …

Kinase inhibitor resistance often involves upregulation of poorly understood “bypass”
signaling pathways. Here, we show that extracellular proteomic adaptation is one path to …

Epithelial–mesenchymal transition (EMT) in cells is a developmental process adopted
during tumorigenesis that promotes metastatic capacity. In this study, we advance …

Background Extracellular signal-regulated kinases (ERKs) have been related to multiple
cancers, including breast cancer, hepatocellular cancer, lung cancer and colorectal cancer …

Extensive preclinical experimentation has conceptually changed the way we perceive breast
cancer, with the wide spectrum of genomic alterations governing its malignant progression …