Sepsis is a major contributor to the global burden of disease. The majority of sepsis cases
and deaths are estimated to occur in low and middle-income countries. Barriers to reducing …

Acute diarrhoeal diseases remain a leading cause of global morbidity and mortality
particularly among young children in resource-limited countries. Recent large studies …

Importance The global patterns and distribution of case-fatality rates (CFRs) in pediatric
severe sepsis and septic shock remain poorly described. Objective We performed a …

Objectives To review epidemiology, aetiology and management of childhood pneumonia in
low-and-middle-income countries. Design Review of published English literature between …

Objectives: More children are surviving critical illness but are at risk of residual or new health
conditions. An evidence-informed and stakeholder-recommended core outcome set is …

Background Children with complicated severe acute malnutrition (SAM) have a greatly
increased risk of mortality from infections while in hospital and after discharge. In HIV …

Background Globally, 85% of acute kidney injury (AKI) cases occur in low-and-middle-
income countries. There is limited information on persistent kidney disease (acute kidney …

Objectives To update the current evidence base on paediatric postdischarge mortality (PDM)
in develo** countries. Secondary objectives included an evaluation of risk factors, timing …

Background Under-five mortality remains concentrated in resource-poor countries. Post-
discharge mortality is becoming increasingly recognized as a significant contributor to …

Background Mass drug administration of azithromycin to children in sub-Saharan Africa has
been shown to improve survival in high-mortality settings. The period after hospital …