The molecular basis of p21-activated kinase-associated neurodevelopmental disorders: From genotype to phenotype
M Dobrigna, S Poëa-Guyon, V Rousseau… - Frontiers in …, 2023 - frontiersin.org
Although the identification of numerous genes involved in neurodevelopmental disorders
(NDDs) has reshaped our understanding of their etiology, there are still major obstacles in …
(NDDs) has reshaped our understanding of their etiology, there are still major obstacles in …
[HTML][HTML] PAKs in the brain: Function and dysfunction
Abstract p21-Activated kinases (PAKs) comprise a family of proteins covering a central role
in signal transduction. They are downstream effectors of Rho GTPases and can affect a …
in signal transduction. They are downstream effectors of Rho GTPases and can affect a …
[HTML][HTML] Disruption of the autism-related gene Pak1 causes stereocilia disorganization, hair cell loss, and deafness in mice
C Cheng, Y Hou, Z Zhang, Y Wang, L Lu… - Journal of Genetics and …, 2021 - Elsevier
Several clinical studies have reported that hearing loss is correlated with autism in children.
However, little is known about the underlying mechanism between hearing loss and autism …
However, little is known about the underlying mechanism between hearing loss and autism …
A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice
DA Simmons, NP Belichenko, EC Ford… - Human molecular …, 2016 - academic.oup.com
Decreases in the ratio of neurotrophic versus neurodegenerative signalling play a critical
role in Huntington's disease (HD) pathogenesis and recent evidence suggests that the p75 …
role in Huntington's disease (HD) pathogenesis and recent evidence suggests that the p75 …
Targeting P21-activated kinase-1 for metastatic prostate cancer
Simple Summary Metastatic prostate cancer (mPCa) results in high mortality and there are
no effective treatments. The molecular mechanisms mediating the transition of early-stage …
no effective treatments. The molecular mechanisms mediating the transition of early-stage …
P-21 activated kinases in liver disorders
Simple Summary Liver disorders, particularly liver cancer and hepatitis, are considered
major public health challenges. Nearly 90% of patients with liver cancer are diagnosed at …
major public health challenges. Nearly 90% of patients with liver cancer are diagnosed at …
Activation of neuronal Ras‐related C3 botulinum toxin substrate 1 (Rac1) improves post‐stroke recovery and axonal plasticity in mice
Long‐term disability after stroke is common but the mechanisms of post‐stroke recovery
remain unclear. Cerebral Ras‐related C3 botulinum toxin substrate (Rac) 1 contributes to …
remain unclear. Cerebral Ras‐related C3 botulinum toxin substrate (Rac) 1 contributes to …
Liposome-mediated delivery of the p21 activated kinase-1 (PAK-1) inhibitor IPA-3 limits prostate tumor growth in vivo
Abstract P21 activated kinases-1 (PAK-1) is implicated in various diseases. It is inhibited by
the small molecule 'inhibitor targeting PAK1 activation-3'(IPA-3), which is highly specific but …
the small molecule 'inhibitor targeting PAK1 activation-3'(IPA-3), which is highly specific but …
PLPP/CIN-mediated NF2 S10 dephosphorylation distinctly regulates kainate-induced seizure susceptibility and neuronal death through PAK1-NF-κB-COX-2-PTGES2 …
JE Kim, DS Lee, TH Kim, H Park, MJ Kim… - Journal of …, 2023 - Springer
Abstract Background Pyridoxal-5′-phosphate phosphatase/chronophin (PLPP/CIN)
selectively dephosphorylates serine (S) 10 site on neurofibromin 2 (NF2, also known as …
selectively dephosphorylates serine (S) 10 site on neurofibromin 2 (NF2, also known as …
The p21‐activated kinase 1 (Pak1) signalling pathway in cardiac disease: from mechanistic study to therapeutic exploration
p21‐activated kinase 1 (Pak1) is a member of the highly conserved family of
serine/threonine protein kinases regulated by Ras‐related small G‐proteins, Cdc42/Rac1. It …
serine/threonine protein kinases regulated by Ras‐related small G‐proteins, Cdc42/Rac1. It …