Synthetic approaches and pharmacological activity of 1, 3, 4-oxadiazoles: a review of the literature from 2000–2012

CS De Oliveira, BF Lira, JM Barbosa-Filho… - Molecules, 2012 - mdpi.com
Molecules | Free Full-Text | Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles:
A Review of the Literature from 2000–2012 Next Article in Journal Chemical Composition of …

An understanding of mechanism-based approaches for 1, 3, 4-oxadiazole scaffolds as cytotoxic agents and enzyme inhibitors

D Kumar, N Aggarwal, A Deep, H Kumar, H Chopra… - Pharmaceuticals, 2023 - mdpi.com
The world's health system is plagued by cancer and a worldwide effort is underway to find
new drugs to treat cancer. There has been a significant improvement in understanding the …

Updates on synthesis and biological activities of 1, 3, 4-oxadiazole: A review

Salahuddin, A Mazumder, MS Yar… - Synthetic …, 2017 - Taylor & Francis
The new era of heterocyclic moieties which are developed in the decades plays a very
important role in the treatment of various diseases. Among them are 1, 3, 4-oxadiazoles, a …

Vasorelaxant and antihypertensive effect of Cocos nucifera Linn. endocarp on isolated rat thoracic aorta and DOCA salt-induced hypertensive rats

GR Bankar, PG Nayak, P Bansal, P Paul… - Journal of …, 2011 - Elsevier
ETHNOPHARMACOLOGICAL RELEVANCE: The fruits of Cocos nucifera Linn.(Arecaceae)
have long been used in traditional medicine for the treatment of cardio-metabolic disorders …

Synthesis, crystal structures, computational studies and antimicrobial activity of new designed bis ((5-aryl-1, 3, 4-oxadiazol-2-yl) thio) alkanes

MN Ahmed, B Sadiq, NA Al-Masoudi, KA Yasin… - Journal of Molecular …, 2018 - Elsevier
A new series of bis ((5-aryl-1, 3, 4-oxadiazol-2-yl) thio) alkanes 4–14 have been synthesized
via nucleophilic substitution reaction of dihaloalkanes with respective 1, 3, 4-oxadiazole-2 …

Design, synthesis, and pharmacology of some oxadiazole and hydroxypyrazoline hybrids bearing thiazoyl scaffold: antiproliferative activity, molecular docking and …

R Santosh, A Prabhu, MK Selvam, PM Krishna… - Heliyon, 2019 - cell.com
A series of oxadiazole (7a-l) and hydroxypyrazoline derivatives (8a-l) incorporating thiazole
were synthesized and characterized by spectral analysis (1 H-NMR, 13 C-NMR, Mass, and …

Synthesis, Molecular Properties Prediction, and Anti-staphylococcal Activity of N-Acylhydrazones and New 1,3,4-Oxadiazole Derivatives

CS De Oliveira, BF Lira, V dos Santos Falcão-Silva… - Molecules, 2012 - mdpi.com
Five new 1-(2-(5-nitrofuran-2-yl)-5-(aryl)-1, 3, 4-oxadiazol-3-(2 H)-yl) ethanone compounds
5a–e were synthesized by cyclization of N-acylhydrazones 4a–e with acetic anhydride …

A comprehensive review on synthetic approaches and biological activities of 1, 3, 4-oxadiazole

S Kumari, R Kumar, A Mazumder… - Mini-Reviews in …, 2022 - benthamdirect.com
Among the large variety of nitrogen and oxygen heterocycles, 1, 3, 4-oxadiazole scaffold has
attracted considerable attention owing to its ability to perform an extensive range of …

A possible correlation between the correction of endothelial dysfunction and normalization of high blood pressure levels by 1, 3, 4-oxadiazole derivative, an L-type …

GR Bankar, GK Nampurath, PG Nayak… - Chemico-biological …, 2010 - Elsevier
We have previously demonstrated the vasorelaxant activity of 1, 3, 4-oxadiazole derivative
(NOX-1) through L-type Ca2+ channel blockage. In the present study, we investigated …

Design, synthesis, DFT calculations, molecular docking and antimicrobial activities of novel cobalt, chromium metal complexes of heterocyclic moiety-based 1, 3, 4 …

T Rohand, H Ben EL Ayouchia, H Achtak… - Journal of …, 2022 - Taylor & Francis
Abstract A Schiff base, 5-(4-methylphenyl)-4-[(pyridin-2-ylmethylidene) amino]-4 H-1, 2, 4-
oxadiazole as a bidentate ligand has been synthesized by the reaction between the 4-amino …