This work is one of our efforts to discover potent anticancer agents. We modified the most
promising derivative of our previous work concerned with the development of VEGFR-2 …

Vascular endothelial growth factor receptor-2 (VEGFR-2), a tyrosine kinase receptor (TKR) is
frequently overexpressed in most of the cancers. It plays a crucial part in tumor angiogenesis …

In our effort to discover potential immunomodulatory anticancer candidates, a new series of
quinazolinone derivatives carrying glutarimide moiety were designed and synthesized as …

Cancer is still a dangerous disease with a high mortality rate all over the world. In our
attempt to develop potential anticancer candidates, new quinazoline and phthalazine based …

A series of coumarin derivatives were designed, synthesized, and evaluated for their
antiproliferative activity. Compound 3e exhibited significant antiproliferative activity and was …

A series of the 2‑hydroxy-3-iodo-5-nitrochalcones 3a–n was synthesized and characterized
spectroscopically (FT-IR, ESI-MS, 1 HNMR, and 13 CNMR) complemented with single …

It is evident that cancer is a serious disease with a growing incidence and high mortality rate.
Based on the CRBN binding properties of glutarimide moiety of thalidomide molecule, and …

New phthalazine derivatives as vascular endothelial growth factor receptor-2 (VEGFR-2)
inhibitors were synthesized joined to different spacers including pyrazole, α, β-unsaturated …

Aim: The current work is an extension to our previous work for the development of new
thalidomide analogs. Materials & methods: Quinazolinone-based molecules carrying a …

Sixteen new thalidomide analogs were synthesized. The new candidates showed potent in
vitro antiproliferative activities against three human cancer cell lines, namely hepatocellular …