The role of inflammation in the pathogenesis of osteoarthritis

YY Chow, KY Chin - Mediators of inflammation, 2020 - Wiley Online Library
A joint is the point of connection between two bones in our body. Inflammation of the joint
leads to several diseases, including osteoarthritis, which is the concern of this review …

Mesenchymal stem cell related therapies for cartilage lesions and osteoarthritis

R Zhang, J Ma, J Han, W Zhang… - American journal of …, 2019 - pmc.ncbi.nlm.nih.gov
Osteoarthritis (OA) is a common degenerative joint disease characterized by cartilage
degradation, synovitis, subchondral bone sclerosis and osteophyte formation. Current …

Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges

M Rahmati, A Mobasheri, M Mozafari - Bone, 2016 - Elsevier
Osteoarthritis (OA) has traditionally been defined as a prototypical non-inflammatory
arthropathy, but today there is compelling evidence to suggest that it has an inflammatory …

[HTML][HTML] Chondrocyte and mesenchymal stem cell-based therapies for cartilage repair in osteoarthritis and related orthopaedic conditions

A Mobasheri, G Kalamegam, G Musumeci, ME Batt - Maturitas, 2014 - Elsevier
Osteoarthritis (OA) represents a final and common pathway for all major traumatic insults to
synovial joints. OA is the most common form of degenerative joint disease and a major …

Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis

KA Waller, LX Zhang, KA Elsaid, BC Fleming… - Proceedings of the …, 2013 - pnas.org
Osteoarthritis is a complex disease involving the mechanical breakdown of articular
cartilage in the presence of altered joint mechanics and chondrocyte death, but the …

Fisetin inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through activating SIRT1 and attenuates the progression of osteoarthritis in …

W Zheng, Z Feng, S You, H Zhang, Z Tao… - International …, 2017 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation
and inflammation. Fisetin, a polyphenol extracted from fruits and vegetables, has been …

Regulation of chondrocyte differentiation by the actin cytoskeleton and adhesive interactions

A Woods, G Wang, F Beier - Journal of cellular physiology, 2007 - Wiley Online Library
Chondrocyte differentiation is a multi‐step process characterized by successive changes in
cell morphology and gene expression. In addition to tight regulation by numerous soluble …

Cell death of chondrocytes is a combination between apoptosis and autophagy during the pathogenesis of Osteoarthritis within an experimental model

M Almonte-Becerril, F Navarro-Garcia… - Apoptosis, 2010 - Springer
The death of chondrocytes and the loss of extracellular matrix are the central features in
cartilage degeneration during Osteoarthritis (OA) pathogenesis. The mechanism by which …

Mesenchymal stem cells in regenerative medicine: opportunities and challenges for articular cartilage and intervertebral disc tissue engineering

SM Richardson, JA Hoyland… - Journal of cellular …, 2010 - Wiley Online Library
Defects of load‐bearing connective tissues such as articular cartilage and intervertebral disc
(IVD) can result from trauma, degenerative, endocrine, or age‐related disease. Current …

Protective effect of ginger (Zingiber officinale roscoe) extract against oxidative stress and mitochondrial apoptosis induced by interleukin-1β in cultured chondrocytes

A Hosseinzadeh, K Bahrampour Juybari… - Cells Tissues …, 2017 - karger.com
Aims: The protective effects of ginger (Zingiber officinale Roscoe) extract on IL-1β-mediated
oxidative stress and mitochondrial apoptosis were investigated in C28I2 human …