The human phenotype ontology in 2017
Deep phenoty** has been defined as the precise and comprehensive analysis of
phenotypic abnormalities in which the individual components of the phenotype are observed …
phenotypic abnormalities in which the individual components of the phenotype are observed …
[PDF][PDF] The human phenotype ontology in 2017
Deep phenoty** has been defined as the precise and comprehensive analysis of
phenotypic abnormalities in which the individual components of the phenotype are observed …
phenotypic abnormalities in which the individual components of the phenotype are observed …
[HTML][HTML] Toxicity by descent: A comparative approach for chemical hazard assessment
JK Colbourne, JR Shaw, E Sostare, C Rivetti… - Environmental …, 2022 - Elsevier
Toxicology is traditionally divided between human and eco-toxicology. In the shared pursuit
of environmental health, this separation does not account for discoveries made in the …
of environmental health, this separation does not account for discoveries made in the …
Found In Translation: a machine learning model for mouse-to-human inference
R Normand, W Du, M Briller, R Gaujoux… - Nature …, 2018 - nature.com
Cross-species differences form barriers to translational research that ultimately hinder the
success of clinical trials, yet knowledge of species differences has yet to be systematically …
success of clinical trials, yet knowledge of species differences has yet to be systematically …
Evolutionary rescue by compensatory mutations is constrained by genomic and environmental backgrounds
M Filteau, V Hamel, MC Pouliot… - Molecular Systems …, 2015 - embopress.org
Since deleterious mutations may be rescued by secondary mutations during evolution,
compensatory evolution could identify genetic solutions leading to therapeutic targets. Here …
compensatory evolution could identify genetic solutions leading to therapeutic targets. Here …
Co-controllability of drug-disease-gene network
PG Sun - New Journal of Physics, 2015 - iopscience.iop.org
Controllability of a single network often focuses on the determination of the network's
minimum dominating set, which aims to elaborate how to control the whole network with …
minimum dominating set, which aims to elaborate how to control the whole network with …
The human drug–disease–gene network
PG Sun - Information Sciences, 2015 - Elsevier
How to understand the correlations of drugs, diseases and genes from a view of network-
based framework is of great importance for disease diagnosis, treatments and drug …
based framework is of great importance for disease diagnosis, treatments and drug …
Yeast phenomics: an experimental approach for modeling gene interaction networks that buffer disease
The genome project increased appreciation of genetic complexity underlying disease
phenotypes: many genes contribute each phenotype and each gene contributes multiple …
phenotypes: many genes contribute each phenotype and each gene contributes multiple …
OMAMO: orthology-based alternative model organism selection
The conservation of pathways and genes across species has allowed scientists to use non-
human model organisms to gain a deeper understanding of human biology. However, the …
human model organisms to gain a deeper understanding of human biology. However, the …
A multi-species functional embedding integrating sequence and network structure
T Lim, T Schaffner, M Crovella - Research in Computational Molecular …, 2018 - Springer
Methods. We introduce a new algorithm, Homology Assessment across Networks using
Diffusion and Landmarks (HANDL), that leverages graph kernels to embed nodes from two …
Diffusion and Landmarks (HANDL), that leverages graph kernels to embed nodes from two …