Mitochondria are cellular organelles responsible for generation of chemical energy in the
process called oxidative phosphorylation. They originate from a bacterial ancestor and …

Mitochondria are the major source of ATP in the cell. Five multi-subunit complexes in the
inner membrane of the organelle are involved in the oxidative phosphorylation required for …

Mitochondria are one of the most important organelles in cells. Mitochondria are semi-
autonomous organelles with their own genetic system, and can independently replicate …

To identify FDA-approved agents targeting leukemic cells, we performed a chemical screen
on two human leukemic cell lines and identified the antimicrobial tigecycline. A genome …

Mitochondria are essential organelles of endosymbiotic origin that are responsible for
oxidative phosphorylation within eukaryotic cells. Independent evolution between species …

Mitochondrial ribosomes (mitoribosomes) perform protein synthesis inside mitochondria, the
organelles responsible for energy conversion and adenosine triphosphate production in …

Mitochondria play fundamental roles in the regulation of life and death of eukaryotic cells.
They mediate aerobic energy conversion through the oxidative phosphorylation (OXPHOS) …

Understanding regulation of mitochondrial DNA (mtDNA) expression is of considerable
interest given that mitochondrial dysfunction is important in human pathology and aging …

Mitochondria maintain their own specialized protein synthesis machinery, which in
mammals is used exclusively for the synthesis of the membrane proteins responsible for …

Protein synthesis in mammalian mitochondria produces 13 proteins that are essential
subunits of the oxidative phosphorylation complexes. This review provides a detailed outline …