Acidic extracellular pH is a major feature of tumor tissue, extracellular acidification being
primarily considered to be due to lactate secretion from anaerobic glycolysis …

Transient receptor potential (TRP) channels are a superfamily of non-selective cation
channels that act as polymodal sensors in many tissues throughout mammalian organisms …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the
degeneration of the nigrostriatal dopaminergic pathway with loss of substantia nigra pars …

Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful
neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential …

This study aims to determine the molecular mechanisms and analgesic effects of transient
receptor potential vanilloid 1 (TRPV1) in the treatments of osteoarthritis (OA) and rheumatoid …

Osteoarthritis (OA) is a currently incurable, chronic, progressive, and debilitating
musculoskeletal (MSK) condition. One of its hallmark symptoms is chronic nociceptive and …

Grip strength deficit is a measure of pain-induced functional disability in rheumatic disease.
We tested whether this parameter and tactile allodynia, the standard pain measure in …

The vanilloid type 1 ion channel (TRPV1) is known to play an important role in the regulation
of pain and inflammation. Pharmacological ligands of TRPV1 regulate human osteoclast …

Cancer pain is a deleterious consequence of tumor growth and related inflammation.
Opioids and anti-inflammatory drugs provide first line treatment for cancer pain, but both are …

Burn injuries are underappreciated injuries associated with substantial morbidity and
mortality. Overexposure to ultraviolet (UV) radiation has dramatic clinical effects in humans …