RAS proteins are conserved guanosine triphosphate (GTP) hydrolases (GTPases) that act
as molecular binary switches and play vital roles in numerous cellular processes. Upon GTP …

Noonan syndrome belongs to the family of RASopathies, a group of multiple congenital
anomaly disorders caused by pathogenic variants in genes encoding components or …

RAS GTPases bind effectors to convert upstream cues to changes in cellular function.
Effectors of classical H/K/NRAS are defined by RBD/RA domains which recognize the GTP …

The term RASopathies designates a group of developmental syndrome that are caused by
activating variants of the RAS/MAPK cascade. The most prevalent clinical diagnosis is …

RASopathies are a group of clinically overlap** autosomal dominant disorders caused
primarily by mutations in genes that reside along the canonical Ras–mitogen-activated …

The RAS family GTPases are the most frequently mutated oncogene family in human
cancers. Activating mutations in either of the three RAS isoforms (HRAS, KRAS, or NRAS) …

Recently, RIT1 has been implicated in a range of neurological disorders; however, its
precise function in glioma pathogenesis is not yet well‐defined. This study employed …

The heart undergoes pathological cardiac hypertrophy as an adaptive response to
prolonged pathological stimulation, leading to cardiomyocyte hypertrophy, fibroblast …

Leucine-zipper–like posttranslational regulator 1 (LZTR1) is a member of the BTB-Kelch
superfamily, which regulates the RAS proteostasis. Autosomal dominant (AD) mutations in …

RIT1 is a rare and understudied oncogene in lung cancer. Despite structural similarity to
other RAS GTPase proteins such as KRAS, oncogenic RIT1 activity does not appear to be …