Potently neutralizing and protective human antibodies against SARS-CoV-2
The ongoing pandemic of coronavirus disease 2019 (COVID-19), which is caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major threat to global health …
Machine learning methods, databases and tools for drug combination prediction
L Wu, Y Wen, D Leng, Q Zhang, C Dai… - Briefings in …, 2022 - academic.oup.com
Combination therapy has shown an obvious efficacy on complex diseases and can greatly
reduce the development of drug resistance. However, even with high-throughput screens …
reduce the development of drug resistance. However, even with high-throughput screens …
SynergyFinder 3.0: an interactive analysis and consensus interpretation of multi-drug synergies across multiple samples
Abstract SynergyFinder (https://synergyfinder. fimm. fi) is a free web-application for
interactive analysis and visualization of multi-drug combination response data. Since its first …
interactive analysis and visualization of multi-drug combination response data. Since its first …
Drug combinations as a first line of defense against coronaviruses and other emerging viruses
The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made develo** …
equipped for future pandemics. While unprecedented strides have been made develo** …
Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1A
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins interact with
the eukaryotic translation machinery, and inhibitors of translation have potent antiviral …
the eukaryotic translation machinery, and inhibitors of translation have potent antiviral …
The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis
Ferroptosis is a type of regulated necrosis caused by unrestricted lipid peroxidation and
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …
subsequent plasma membrane rupture. However, the lipid remodeling mechanism that …
SynergyFinder plus: toward better interpretation and annotation of drug combination screening datasets
Combinatorial therapies have been recently proposed to improve the efficacy of anticancer
treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug …
treatment. The SynergyFinder R package is a software used to analyze pre-clinical drug …
Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal cancer by preventing PANoptosis
JF Lin, PS Hu, YY Wang, YT Tan, K Yu, K Liao… - Signal transduction and …, 2022 - nature.com
Metabolic enzymes have an indispensable role in metabolic reprogramming, and their
aberrant expression or activity has been associated with chemosensitivity. Hence, targeting …
aberrant expression or activity has been associated with chemosensitivity. Hence, targeting …
Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay
WD Jang, S Jeon, S Kim… - Proceedings of the …, 2021 - National Acad Sciences
The COVID-19 pandemic caused by SARS-CoV-2 is an unprecedentedly significant health
threat, prompting the need for rapidly develo** antiviral drugs for the treatment. Drug …
threat, prompting the need for rapidly develo** antiviral drugs for the treatment. Drug …
Clofazimine broadly inhibits coronaviruses including SARS-CoV-2
The COVID-19 pandemic is the third outbreak this century of a zoonotic disease caused by a
coronavirus, following the emergence of severe acute respiratory syndrome (SARS) in 2003 …
coronavirus, following the emergence of severe acute respiratory syndrome (SARS) in 2003 …