In recent years, the understanding of regulatory T cell (Treg cell) biology has expanded
considerably. Key observations have challenged the traditional definition of Treg cells and …

Regulatory T (Treg) cells constitute a dynamic population that is essential for controlling
immune responses in health and disease. Defects in Treg cell function and decreases in …

Abstract The PI3K/AKT signaling pathway is an essential node in mammalian cells that
controls cell growth, migration, proliferation, and metabolism. During the last decade, a …

The T cell co-stimulatory molecule OX40 and its cognate ligand OX40L have attracted broad
research interest as a therapeutic target in T cell-mediated diseases. Accumulating …

FOXP3+ Tregs rely on fatty acid β-oxidation–driven (FAO-driven) oxidative phosphorylation
(OXPHOS) for differentiation and function. Recent data demonstrate a role for Tregs in the …

Purpose To review the pathogenesis of uveitis in light of recent advances in our
understanding of innate and adaptive immune responses and their regulation. Design …

Regulatory T cells (Tregs), a suppressive subpopulation of T cells, are potent mediators of
peripheral tolerance, responsible for immune homeostasis. Many autoimmune diseases …

Regulatory T cells (Treg) represent a subset of specialized T cells that are essential for the
regulation of immune responses and maintenance of peripheral tolerance. Once activated …

Regulatory T cells (Tregs) possess unique immunosuppressive activity among CD4-positive
T cells. Tregs are ubiquitously present in mammals and function to calm excessive immune …

FOXP3‐expressing regulatory T cells (Treg) are indispensable for immune homeostasis and
tolerance, and in addition tissue‐resident Treg have been found to perform noncanonical …