Ageing is the predominant risk factor for many common diseases. Human premature ageing
diseases are powerful model systems to identify and characterize cellular mechanisms that …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

Because of the association between aberrant nuclear structure and tumour grade, nuclear
morphology is an indispensible criterion in the current pathological assessment of cancer …

One of the many debated topics in ageing research is whether progeroid syndromes are
really accelerated forms of human ageing. The answer requires a better understanding of …

Mesenchymal stem cells (MSCs) have been used in cell-based therapy for various diseases,
due to their immunomodulatory and inflammatory effects. However, the function of MSCs is …

Abstract Therapy-Induced Senescence (TIS) is an established response to anticancer
therapy in a variety of cancer models. Ample evidence has characterized the triggers …

A‐type lamins are intermediate filament proteins that provide a scaffold for protein
complexes regulating nuclear structure and function. Mutations in the LMNA gene are linked …

Telomeres protect the ends of linear genomes, and the gradual loss of telomeres is
associated with cellular ageing. Telomere protection involves the insertion of the 3 …

Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature-aging syndrome caused by a
dominant mutation in the gene encoding lamin A, which leads to an aberrantly spliced and …

Abstract Exosomes are small (30-100nm) vesicles secreted from all cell types serving as
inter-cell communicators and affecting biological processes in “recipient” cells upon their …