How the shape of embryos and organs emerges during development is a fundamental
question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …

The generation of organismal form—morphogenesis—arises from forces produced at the
cellular level. In animal cells, much of this force is produced by the actin cytoskeleton. Here …

INTRODUCTION How biological properties scale with organ or body size is a question
fundamental to development and physiology; however, at the cellular level, the scaling …

With the advent of mechanobiology, cell shape and forces have emerged as essential
elements of cell behavior and fate, in addition to biochemical factors such as growth factors …

Collective cell migration is an essential process throughout the lives of multicellular
organisms, for example in embryonic development, wound healing and tumour metastasis …

During embryonic development, a simple ball of cells re-shapes itself into the elaborate
body plan of an animal. This requires dramatic cell shape changes and cell movements …

The differentiation of primordial germ cells (PGCs) occurs during early embryonic
development and is critical for the survival and fitness of sexually reproducing species. Here …

Apical constriction driven by actin and non-muscle myosin II (actomyosin) provides a well-
conserved mechanism to mediate epithelial folding. It remains unclear how contractile forces …

ABSTRACT A characteristic of normal aging and age-related diseases is the remodeling of
the cellular organization of a tissue through polyploid cell growth. Polyploidy arises from an …

A critical juncture in early development is the partitioning of cells that will adopt different
fates into three germ layers: the ectoderm, the mesoderm, and the endoderm. This step is …