Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
not translated into proteins. Since their discovery, ncRNAs have emerged as important …
Noncoding RNA therapeutics—challenges and potential solutions
Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of …
Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies
S Paul, E Candelario-Jalil - Experimental neurology, 2021 - Elsevier
Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …
With the global population aged 65 and over growing faster than all other age groups, the …
MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
In just over two decades since the discovery of the first microRNA (miRNA), the field of
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
miRNA biology has expanded considerably. Insights into the roles of miRNAs in …
Non-coding RNAs and ferroptosis: potential implications for cancer therapy
Ferroptosis is a recently defined form of regulated cell death, which is biochemically and
morphologically distinct from traditional forms of programmed cell death such as apoptosis …
morphologically distinct from traditional forms of programmed cell death such as apoptosis …
The role of MicroRNAs in human cancer
Y Peng, CM Croce - Signal transduction and targeted therapy, 2016 - nature.com
MicroRNAs (miRNAs) are endogenous, small non-coding RNAs that function in regulation of
gene expression. Compelling evidences have demonstrated that miRNA expression is …
gene expression. Compelling evidences have demonstrated that miRNA expression is …
Modulating epigenetic modifications for cancer therapy
LJ Castro-Muñoz, E Vázquez Ulloa… - Oncology …, 2023 - spandidos-publications.com
Cancer is a global public health concern. Alterations in epigenetic processes are among the
earliest genomic aberrations occurring during cancer development and are closely related …
earliest genomic aberrations occurring during cancer development and are closely related …
Clustered miRNAs and their role in biological functions and diseases
MicroRNAs (miRNAs) are endogenous, small non‐coding RNAs known to regulate
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
expression of protein‐coding genes. A large proportion of miRNAs are highly conserved …
Molecular mechanisms of apoptosis and roles in cancer development and treatment
Programmed cell death (PCD) or apoptosis is a mechanism which is crucial for all
multicellular organisms to control cell proliferation and maintain tissue homeostasis as well …
multicellular organisms to control cell proliferation and maintain tissue homeostasis as well …
MicroRNAs and other non-coding RNAs as targets for anticancer drug development
The first cancer-targeted microRNA (miRNA) drug—MRX34, a liposome-based miR-34
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …
mimic—entered Phase I clinical trials in patients with advanced hepatocellular carcinoma in …