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Innate immune evasion strategies of SARS-CoV-2
Abstract SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been
associated with substantial global morbidity and mortality. Despite a tropism that is largely …
associated with substantial global morbidity and mortality. Despite a tropism that is largely …
[HTML][HTML] COVID-19, post-acute COVID-19 syndrome (PACS,“long COVID”) and post-COVID-19 vaccination syndrome (PCVS,“post-COVIDvac-syndrome”): Similarities …
Worldwide there have been over 760 million confirmed coronavirus disease 2019 (COVID-
19) cases, and over 13 billion COVID-19 vaccine doses have been administered as of April …
19) cases, and over 13 billion COVID-19 vaccine doses have been administered as of April …
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency
Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …
autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I …
Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia
Recessive or dominant inborn errors of type I interferon (IFN) immunity can underlie critical
COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in …
COVID-19 pneumonia in unvaccinated adults. The risk of COVID-19 pneumonia in …
Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in∼ 40% of patients
Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause
encephalitis in< 1% of infected individuals. We show that∼ 35% of patients hospitalized for …
encephalitis in< 1% of infected individuals. We show that∼ 35% of patients hospitalized for …
[HTML][HTML] From rare disorders of immunity to common determinants of infection: Following the mechanistic thread
The immense interindividual clinical variability during any infection is a long-standing
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …
enigma. Inborn errors of IFN-γ and IFN-α/β immunity underlying rare infections with weakly …
Autoantibodies against type I IFNs in patients with critical influenza pneumonia
Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19
pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring …
pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring …
The ouroboros of autoimmunity
Human autoimmunity against elements conferring protective immunity can be symbolized by
the 'ouroboros', a snake eating its own tail. Underlying infection is autoimmunity against …
the 'ouroboros', a snake eating its own tail. Underlying infection is autoimmunity against …
The microbe, the infection enigma, and the host
Human infectious diseases are unique in that the discovery of their environmental trigger,
the microbe, was sufficient to drive the development of extraordinarily effective principles …
the microbe, was sufficient to drive the development of extraordinarily effective principles …
Human life within a narrow range: The lethal ups and downs of type I interferons
The past 20 years have seen the definition of human monogenic disorders and their
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …
autoimmune phenocopies underlying either defective or enhanced type I interferon (IFN) …