Unlocking the potential of drug-drug cocrystals–A comprehensive review

M Banerjee, K Nimkar, S Naik, V Patravale - Journal of Controlled Release, 2022 - Elsevier
Intensive research subjected to the improvement of solubility and bioavailability of certain
drugs has popularized the formation of cocrystals, wherein the desired drug is non-ionically …

Co-crystal nanoarchitectonics as an emerging strategy in attenuating cancer: Fundamentals and applications

P Kumbhar, K Kolekar, C Khot, S Dabhole… - Journal of Controlled …, 2023 - Elsevier
Cancer ranks as the second foremost cause of death in various corners of the globe. The
clinical uses of assorted anticancer therapeutics have been limited owing to the poor …

Enhanced stability and oral bioavailability of erlotinib by solid self nano emulsifying drug delivery systems

S Jain, K Dongare, B Nallamothu, CP Dora… - International Journal of …, 2022 - Elsevier
The present investigation demonstrates the preparation of solid self nanoemulsfying drug
delivery system (sSNEDDS) to enhance stability and bioavailability of Erlotinib (ERL) via the …

Cocrystals and drug–drug cocrystals of anticancer drugs: A perception towards screening techniques, preparation, and enhancement of drug properties

DD Kara, M Rathnanand - Crystals, 2022 - mdpi.com
The most favored approach for drug administration is the oral route. Several anticancer
drugs come under this category and mostly lack solubility and oral bioavailability, which are …

Cocrystallization of lenvatinib and temozolomide to improve the performance in terms of stability, dissolution, and tabletability

ZQ Wang, XL Dai, DL Gu, C Wu, TB Lu, XT Long… - …, 2023 - pubs.rsc.org
Two anti-melanoma drugs, lenvatinib and temozolomide, were cocrystallized to obtain two
drug–drug cocrystal solvates, TMZ–LEN· MeOH (1: 1: 1) and TMZ–LEN· EtOH (1: 1: 1). They …

Molecular structures of eight hydrogen bond-mediated minoxidil adducts from different aryl acids

X Ma, X Chen, Y Zhen, X Zheng, C Shi, S **… - Journal of Molecular …, 2024 - Elsevier
Cocrystallization experiments between the widely popular active pharmaceutical ingredient
(API) minoxidil and an array of aryl acids coformers were carried out, successfully yielding 8 …

Cocrystal design of vanillin with amide drugs: Crystal structure determination, solubility enhancement, DFT calculation

J Ouyang, X **ng, L Zhou, C Zhang… - … Engineering Research and …, 2022 - Elsevier
Vanillin (VAN) is widely used in medicine, food and optoelectronics, but its low solubility
leads to the decrease of bioavailability and increase of application costs. Three APIs …

“Drug–Coformer–Drug” Multicomponent Crystals to Simultaneously Improve the Solubility of Two Insoluble Combined Drugs by Introduction of a Soluble Coformer

BY Ren, XL Dai, F Zhang, X Long… - Crystal Growth & …, 2022 - ACS Publications
One “drug–drug”(GTB–RH) and two “drug–coformer–drug”(GTB–SA–RH and GTB–SA–RH·
EtOH) multicomponent crystals involving two insoluble drugs, gefitinib (GTB) and rhein (RH) …

A drug–drug cocrystal of dihydromyricetin and pentoxifylline

L Liu, Y Li, M Zhang, Y Zhang, B Lou - Journal of Pharmaceutical Sciences, 2022 - Elsevier
Drug–drug cocrystals, which can regulate physicochemical properties of individual drugs
and might produce synergistic therapeutic effects, have drawn growing interest in the …

Strategy to Tune the Performance of Two Drug Components: Drug–Drug Cocrystals of Lobaplatin with Flavonoids

HM Yin, JY **e, JY Jiang, M Hong, B Zhu… - Crystal Growth & …, 2022 - ACS Publications
A cocrystallization technique was utilized to improve the performance of lobaplatin, and five
cocrystals of lobaplatin with a variety of flavonoids, including quercetin, myricetin, fisetin …