Unlocking the potential of drug-drug cocrystals–A comprehensive review
Intensive research subjected to the improvement of solubility and bioavailability of certain
drugs has popularized the formation of cocrystals, wherein the desired drug is non-ionically …
drugs has popularized the formation of cocrystals, wherein the desired drug is non-ionically …
Co-crystal nanoarchitectonics as an emerging strategy in attenuating cancer: Fundamentals and applications
Cancer ranks as the second foremost cause of death in various corners of the globe. The
clinical uses of assorted anticancer therapeutics have been limited owing to the poor …
clinical uses of assorted anticancer therapeutics have been limited owing to the poor …
Enhanced stability and oral bioavailability of erlotinib by solid self nano emulsifying drug delivery systems
The present investigation demonstrates the preparation of solid self nanoemulsfying drug
delivery system (sSNEDDS) to enhance stability and bioavailability of Erlotinib (ERL) via the …
delivery system (sSNEDDS) to enhance stability and bioavailability of Erlotinib (ERL) via the …
Cocrystals and drug–drug cocrystals of anticancer drugs: A perception towards screening techniques, preparation, and enhancement of drug properties
The most favored approach for drug administration is the oral route. Several anticancer
drugs come under this category and mostly lack solubility and oral bioavailability, which are …
drugs come under this category and mostly lack solubility and oral bioavailability, which are …
Cocrystallization of lenvatinib and temozolomide to improve the performance in terms of stability, dissolution, and tabletability
ZQ Wang, XL Dai, DL Gu, C Wu, TB Lu, XT Long… - …, 2023 - pubs.rsc.org
Two anti-melanoma drugs, lenvatinib and temozolomide, were cocrystallized to obtain two
drug–drug cocrystal solvates, TMZ–LEN· MeOH (1: 1: 1) and TMZ–LEN· EtOH (1: 1: 1). They …
drug–drug cocrystal solvates, TMZ–LEN· MeOH (1: 1: 1) and TMZ–LEN· EtOH (1: 1: 1). They …
Molecular structures of eight hydrogen bond-mediated minoxidil adducts from different aryl acids
X Ma, X Chen, Y Zhen, X Zheng, C Shi, S **… - Journal of Molecular …, 2024 - Elsevier
Cocrystallization experiments between the widely popular active pharmaceutical ingredient
(API) minoxidil and an array of aryl acids coformers were carried out, successfully yielding 8 …
(API) minoxidil and an array of aryl acids coformers were carried out, successfully yielding 8 …
Cocrystal design of vanillin with amide drugs: Crystal structure determination, solubility enhancement, DFT calculation
J Ouyang, X **ng, L Zhou, C Zhang… - … Engineering Research and …, 2022 - Elsevier
Vanillin (VAN) is widely used in medicine, food and optoelectronics, but its low solubility
leads to the decrease of bioavailability and increase of application costs. Three APIs …
leads to the decrease of bioavailability and increase of application costs. Three APIs …
“Drug–Coformer–Drug” Multicomponent Crystals to Simultaneously Improve the Solubility of Two Insoluble Combined Drugs by Introduction of a Soluble Coformer
BY Ren, XL Dai, F Zhang, X Long… - Crystal Growth & …, 2022 - ACS Publications
One “drug–drug”(GTB–RH) and two “drug–coformer–drug”(GTB–SA–RH and GTB–SA–RH·
EtOH) multicomponent crystals involving two insoluble drugs, gefitinib (GTB) and rhein (RH) …
EtOH) multicomponent crystals involving two insoluble drugs, gefitinib (GTB) and rhein (RH) …
A drug–drug cocrystal of dihydromyricetin and pentoxifylline
L Liu, Y Li, M Zhang, Y Zhang, B Lou - Journal of Pharmaceutical Sciences, 2022 - Elsevier
Drug–drug cocrystals, which can regulate physicochemical properties of individual drugs
and might produce synergistic therapeutic effects, have drawn growing interest in the …
and might produce synergistic therapeutic effects, have drawn growing interest in the …
Strategy to Tune the Performance of Two Drug Components: Drug–Drug Cocrystals of Lobaplatin with Flavonoids
HM Yin, JY **e, JY Jiang, M Hong, B Zhu… - Crystal Growth & …, 2022 - ACS Publications
A cocrystallization technique was utilized to improve the performance of lobaplatin, and five
cocrystals of lobaplatin with a variety of flavonoids, including quercetin, myricetin, fisetin …
cocrystals of lobaplatin with a variety of flavonoids, including quercetin, myricetin, fisetin …