Evidence from physical sciences in oncology increasingly suggests that the interplay
between the biophysical tumor microenvironment and genetic regulation has significant …

The mechanical properties of cells and tissues help determine their architecture,
composition and function. Alterations to these properties are associated with many diseases …

Although historically, the traditional bidimensional in vitro cell system has been widely used
in research, providing much fundamental information regarding cellular functions and …

Cell culture has become an indispensable tool to help uncover fundamental biophysical and
biomolecular mechanisms by which cells assemble into tissues and organs, how these …

Although the biological functions of cell and tissue can be regulated by biochemical factors
(eg, growth factors, hormones), the biophysical effects of materials on the regulation of …

In vitro tumor models have provided important tools for cancer research and serve as low-
cost screening platforms for drug therapies; however, cancer recurrence remains largely …

Cell adhesion is essential in cell communication and regulation, and is of fundamental
importance in the development and maintenance of tissues. The mechanical interactions …

The tumor microenvironment is a dynamic landscape in which the physical and mechanical
properties evolve dramatically throughout cancer progression. These changes are driven by …

Control of the structure and function of three-dimensional multicellular tissues depends
critically on the spatial and temporal coordination of cellular physical properties, yet the …

Biointerfaces mediate safe and efficient cell manipulation, which is essential for biomedical
innovations in advanced therapies and diagnostics. The biointerface established by vertical …