Stem cells (SCs) maintain tissue homeostasis and repair wounds. Despite marked variation
in tissue architecture and regenerative demands, SCs often follow similar paradigms in …

Quiescence is a state of reversible proliferative arrest in which cells are not actively dividing
and yet retain the capacity to reenter the cell cycle upon receiving an appropriate stimulus …

Empirical and anecdotal evidence has associated stress with accelerated hair greying
(formation of unpigmented hairs),, but so far there has been little scientific validation of this …

Chronic, sustained exposure to stressors can profoundly affect tissue homeostasis, although
the mechanisms by which these changes occur are largely unknown. Here we report that the …

Skin architecture and function depend on diverse populations of epidermal cells and dermal
fibroblasts. Reciprocal communication between the epidermis and dermis plays a key role in …

Although normally dormant, hair follicle stem cells (HFSCs) quickly become activated to
divide during a new hair cycle. The quiescence of HFSCs is known to be regulated by a …

Piloerection (goosebumps) requires concerted actions of the hair follicle, the arrector pili
muscle (APM), and the sympathetic nerve, providing a model to study interactions across …

Stem cells are critical for the maintenance of many tissues, but whether their integrity is
maintained in the face of immunity is unclear. Here we found that cycling epithelial stem …

Hair follicles, which are connected to sebaceous glands in the skin, undergo cyclic periods
of regeneration, degeneration, and rest throughout adult life in mammals. The crucial …

Aging manifests with architectural alteration and functional decline of multiple organs
throughout an organism. In mammals, aged skin is accompanied by a marked reduction in …