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Emerging roles and functional mechanisms of PIWI-interacting RNAs
PIWI-interacting RNAs (piRNAs) are a class of small non-coding RNAs that associate with
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …
proteins of the PIWI clade of the Argonaute family. First identified in animal germ line cells …
[HTML][HTML] Life of RISC: Formation, action, and degradation of RNA-induced silencing complex
Small RNAs regulate a wide variety of biological processes by repressing the expression of
target genes at the transcriptional and post-transcriptional levels. To achieve these …
target genes at the transcriptional and post-transcriptional levels. To achieve these …
PIWI-interacting RNAs: small RNAs with big functions
In animals, PIWI-interacting RNAs (piRNAs) of 21–35 nucleotides in length silence
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
transposable elements, regulate gene expression and fight viral infection. piRNAs guide …
Intergenerational and transgenerational epigenetic inheritance in animals
Animals transmit not only DNA but also other molecules, such as RNA, proteins and
metabolites, to their progeny via gametes. It is currently unclear to what extent these …
metabolites, to their progeny via gametes. It is currently unclear to what extent these …
The emerging role of the piRNA/piwi complex in cancer
Y Liu, M Dou, X Song, Y Dong, S Liu, H Liu, J Tao, W Li… - Molecular cancer, 2019 - Springer
Piwi interacting RNAs (piRNAs) constitute novel small non-coding RNA molecules of
approximately 24–31 nucleotides in length that often bind to members of the piwi protein …
approximately 24–31 nucleotides in length that often bind to members of the piwi protein …
Transgenerational epigenetic inheritance
Inheritance of genomic DNA underlies the vast majority of biological inheritance, yet it has
been clear for decades that additional epigenetic information can be passed on to future …
been clear for decades that additional epigenetic information can be passed on to future …
RNA-mediated epigenetic regulation of gene expression
Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key
regulators of gene expression, genome stability and defence against foreign genetic …
regulators of gene expression, genome stability and defence against foreign genetic …
Small RNAs are trafficked from the epididymis to develo** mammalian sperm
The biogenesis of the RNA payload of mature sperm is of great interest, because RNAs
delivered to the zygote at fertilization can affect early development. Here, we tested the …
delivered to the zygote at fertilization can affect early development. Here, we tested the …
Host–transposon interactions: conflict, cooperation, and cooption
Transposable elements (TEs) are mobile DNA sequences that colonize genomes and
threaten genome integrity. As a result, several mechanisms appear to have emerged during …
threaten genome integrity. As a result, several mechanisms appear to have emerged during …
A comprehensive survey of C. elegans argonaute proteins reveals organism-wide gene regulatory networks and functions
Argonaute (AGO) proteins associate with small RNAs to direct their effector function on
complementary transcripts. The nematode Caenorhabditis elegans contains an expanded …
complementary transcripts. The nematode Caenorhabditis elegans contains an expanded …