Metabolic alterations upon SARS-CoV-2 infection and potential therapeutic targets against coronavirus infection
Abstract The coronavirus disease 2019 (COVID-19) caused by coronavirus SARS-CoV-2
infection has become a global pandemic due to the high viral transmissibility and …
infection has become a global pandemic due to the high viral transmissibility and …
Large-scale plasma analysis revealed new mechanisms and molecules associated with the host response to SARS-CoV-2
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to
nearly every continent, registering over 1,250,000 deaths worldwide. The effects of SARS …
nearly every continent, registering over 1,250,000 deaths worldwide. The effects of SARS …
Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism
Although the immunomodulatory and cytoprotective properties of itaconate have been
studied extensively, it is not known whether its naturally occurring isomers mesaconate and …
studied extensively, it is not known whether its naturally occurring isomers mesaconate and …
Longitudinal metabolomics of human plasma reveals prognostic markers of COVID-19 disease severity
There is an urgent need to identify which COVID-19 patients will develop life-threatening
illness so that medical resources can be optimally allocated and rapid treatment can be …
illness so that medical resources can be optimally allocated and rapid treatment can be …
Exploring Virulence Factors and Alternative Therapies against Staphylococcus aureus Pneumonia
Pneumonia is an acute pulmonary infection associated with high mortality and an immense
financial burden on healthcare systems. Staphylococcus aureus is an opportunistic …
financial burden on healthcare systems. Staphylococcus aureus is an opportunistic …
Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients
The IMPACC cohort, composed of> 1,000 hospitalized COVID-19 participants, contains five
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1 …
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1 …
ISG15 deficiency features a complex cellular phenotype that responds to treatment with itaconate and derivatives
SFH Waqas, A Sohail, AHH Nguyen… - Clinical and …, 2022 - Wiley Online Library
Background Congenital ISG15 deficiency is a rare autoinflammatory disorder that is driven
by chronically elevated systemic interferon levels and predominantly affects central nervous …
by chronically elevated systemic interferon levels and predominantly affects central nervous …
Lipidomic signatures align with inflammatory patterns and outcomes in critical illness
Alterations in lipid metabolism have the potential to be markers as well as drivers of
pathobiology of acute critical illness. Here, we took advantage of the temporal precision …
pathobiology of acute critical illness. Here, we took advantage of the temporal precision …
Identifying potential biomarkers and therapeutic targets for dogs with sepsis using metabolomics and lipidomics analyses
B Montague, A Summers, R Bhawal, ET Anderson… - PloS one, 2022 - journals.plos.org
Sepsis is a diagnostic and therapeutic challenge and is associated with morbidity and a high
risk of death. Metabolomic and lipidomic profiling in sepsis can identify alterations in …
risk of death. Metabolomic and lipidomic profiling in sepsis can identify alterations in …
[HTML][HTML] Myristoyl lysophosphatidylcholine is a biomarker and potential therapeutic target for community-acquired pneumonia
W Nan, F **ong, H Zheng, C Li, C Lou, X Lei, H Wu… - Redox biology, 2022 - Elsevier
There is no gold standard for evaluating the severity of community-acquired pneumonia
(CAP), and it is still based on a score. This study aimed to use the metabolomics method to …
(CAP), and it is still based on a score. This study aimed to use the metabolomics method to …