Histone demethylase LSD1 plays key roles during carcinogenesis, targeting LSD1 is
becoming an emerging option for the treatment of cancers. Numerous LSD1 inhibitors have …

Histone lysine-specific demethylase 1 (LSD1/KDM1A) has become an important and
promising anticancer target since it was first identified in 2004 and specially demethylates …

Epigenetic regulation of gene expression plays a critical role in various physiological
processes, and epigenetic dysregulation is implicated in a number of diseases, prominently …

Inhibition of lysine specific demethylase 1 (LSD1) has been shown to induce the
differentiation of leukemia stem cells in acute myeloid leukemia (AML). Irreversible inhibitors …

FAD-dependent lysine-specific demethylase 1 (LSD1) is overexpressed or deregulated in
many cancers such as AML and prostate cancer and hence is a promising anticancer target …

Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
memory loss and cognitive decline, which are consequences of chronic progressive …

Tranylcypromine (TCP)-based structural modifications lead to the discovery of new LSD1
inhibitors, of which compounds 26b and 29b effectively inhibit LSD1 with the IC 50 values of …

Histone lysine methylation, one of the epigenetic mechanisms, plays a pivotal role in various
biological events, including cell cycle progression, immune response, and signal …

US10780081B2 - Method of treating multiple sclerosis employing a LSD1-inhibitor - Google
Patents US10780081B2 - Method of treating multiple sclerosis employing a LSD1-inhibitor …