Fumagillin is a mycotoxin produced, above all, by the saprophytic filamentous fungus
Aspergillus fumigatus. This mold is an opportunistic pathogen that can cause invasive …

Abstract The cysteine/arginine (Cys/Arg) branch of the N-degron pathway controls the
stability of certain proteins with methionine (Met)-Cys N-termini, initiated by Met cleavage …

Aptamer-based proteomics revealed differentially abundant proteins in Alzheimer's disease
(AD) brains in the Baltimore Longitudinal Study of Aging and Religious Orders Study (mean …

Protein acetylation is a highly frequent protein modification. However, comparatively little is
known about its enzymatic machinery. N‐α‐acetylation (NTA) and ε‐lysine acetylation (KA) …

An organism's entire protein modification repertoire has yet to be comprehensively mapped.
N-myristoylation (MYR) is a crucial eukaryotic N-terminal protein modification. Here we …

LINC00461 is located in the intergenic region between the protein-coding genes MEF2C
and TMEM161B. LINC00461 upregulation was associated with the risk of 13 tumors and …

BACKGROUND: Preeclampsia is a hypertensive disorder of pregnancy characterized by
systemic endothelial dysfunction. The pathophysiology of preeclampsia remains …

All organisms begin protein synthesis with methionine (Met). The resulting initiator Met of
nascent proteins is irreversibly processed by Met aminopeptidases (MetAPs). N-terminal (Nt) …

Tezosentan is a vasodilator drug that was originally developed to treat pulmonary arterial
hypertension. It acts by inhibiting endothelin (ET) receptors, which are overexpressed in …

Acetyl-CoA participates in post-translational modification of proteins and in central carbon
and lipid metabolism in several cell compartments. In mammals, acetyl-CoA transporter 1 …