The development and functions of multiciliated epithelia

N Spassky, A Meunier - Nature reviews Molecular cell biology, 2017 - nature.com
Multiciliated cells are epithelial cells that are in contact with bodily fluids and are required for
the proper function of major organs including the brain, the respiratory system and the …

Roles of ependymal cells in the physiology and pathology of the central nervous system

S Deng, L Gan, C Liu, T Xu, S Zhou, Y Guo… - Aging and …, 2023 - pmc.ncbi.nlm.nih.gov
Ependymal cells are indispensable components of the central nervous system (CNS). They
originate from neuroepithelial cells of the neural plate and show heterogeneity, with at least …

Ependymal cells: biology and pathology

MR Del Bigio - Acta neuropathologica, 2010 - Springer
The literature was reviewed to summarize the current understanding of the role of ciliated
ependymal cells in the mammalian brain. Previous reviews were summarized. Publications …

Structure and function of the ependymal barrier and diseases associated with ependyma disruption

AJ Jiménez, MD Domínguez-Pinos, MM Guerra… - Tissue …, 2014 - Taylor & Francis
The neuroepithelium is a germinal epithelium containing progenitor cells that produce
almost all of the central nervous system cells, including the ependyma. The neuroepithelium …

Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation

I Ibañez-Tallon, A Pagenstecher… - Human molecular …, 2004 - academic.oup.com
Motility of unicellular organisms occurred early in evolution with the emergence of cilia and
flagella. In vertebrates, motile cilia are required for numerous functions such as clearance of …

Mechanisms of hydrocephalus after neonatal and adult intraventricular hemorrhage

J Strahle, HJL Garton, CO Maher, KM Muraszko… - Translational stroke …, 2012 - Springer
Intraventricular hemorrhage (IVH) is a cause of significant morbidity and mortality and is an
independent predictor of a worse outcome in intracerebral hemorrhage (ICH) and germinal …

Functional topography of midbrain and pontine serotonergic systems: implications for synaptic regulation of serotonergic circuits

MW Hale, CA Lowry - Psychopharmacology, 2011 - Springer
Rationale Dysfunction of serotonergic systems is thought to play an important role in a
number of neurological and psychiatric disorders. Recent studies suggest that there is …

[HTML][HTML] The role of adult neurogenesis in psychiatric and cognitive disorders

DM Apple, RS Fonseca, E Kokovay - Brain research, 2017 - Elsevier
Neurogenesis in mammals occurs throughout life in two brain regions: the ventricular–
subventricular zone (V–SVZ) and the subgranular zone (SGZ) of the hippocampal dentate …

Stress-related serotonergic systems: implications for symptomatology of anxiety and affective disorders

MW Hale, A Shekhar, CA Lowry - Cellular and molecular neurobiology, 2012 - Springer
Previous studies have suggested that serotonergic neurons in the midbrain raphe complex
have a functional topographic organization. Recent studies suggest that stimulation of a bed …

Multiciliated ependymal cells: an update on biology and pathology in the adult brain

AMR Groh, YL Song, F Tea, B Lu, S Huynh… - Acta …, 2024 - Springer
Mature multiciliated ependymal cells line the cerebral ventricles where they form a partial
barrier between the cerebrospinal fluid (CSF) and brain parenchyma and regulate local CSF …