The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the
risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly …

In this review, we focus on recent developments in our understanding of nutrient-induced
insulin secretion that challenge a key aspect of the" canonical" model, in which an oxidative …

Pancreatic β-cells produce and secrete insulin to maintain blood glucose levels within a
narrow range. Defects in the function and mass of β-cells play a significant role in the …

Over the last decades, epidemiology and functional studies have started to reveal a pivotal
role of vitamin D in both type 1 and type 2 diabetes pathogenesis. Acting through the vitamin …

Abstract Purpose of Review To discuss evidence supporting the use of glucagon-like
peptide 1 receptor agonists (GLP-1RA) to treat obesity and their role as a cardioprotective …

Insulin is a life-saving drug for patients with type 1 diabetes; however, even today, no
pharmacotherapy can prevent the loss or dysfunction of pancreatic insulin-producing β cells …

Pancreatic β-cell compensation is a major mechanism in delaying T2DM progression. Here
we report the abnormal high expression of circGlis3 in islets of male mice with obesity and …

Hyperinsulinemia often precedes type 2 diabetes. Palmitoylation, implicated in exocytosis, is
reversed by acyl-protein thioesterase 1 (APT1). APT1 biology was altered in pancreatic …

Background It is unclear how excess adiposity and insulin resistance affect β cell function,
insulin secretion, and insulin clearance in people with obesity. Methods We used a …

Plastic pollution breaks a planetary boundary threatening wildlife and humans through its
physical and chemical effects. Of the latter, the release of endocrine disrupting chemicals …