Polarized epithelial cells play fundamental roles in the ontogeny and function of a variety of
tissues and organs in mammals. The morphogenesis of a sheet of polarized epithelial cells …

Diarrhea is common in infants (children less than 2 years of age), usually acute, and, if
chronic, commonly caused by allergies and occasionally by infectious agents. Congenital …

Diarrhoeal disease remains a major health burden worldwide. Secretory diarrhoeas are
caused by certain bacterial and viral infections, inflammatory processes, drugs and genetic …

A model system is described for defining the physiologic functions of mammalian cadherins
in vivo. 129/Sv embryonic stem (ES) cells, stably transfected with a dominant negative N …

A combination of approaches has begun to elucidate the mechanisms of gastrointestinal
development. This review describes progress over the last 20 years in understanding …

For decades, enterocyte brush border microvilli have been viewed as passive cytoskeletal
scaffolds that serve to increase apical membrane surface area. However, recent studies …

Cells of transporting epithelia are characterized by the presence of abundant F-actin-based
microvilli on their apical surfaces. Likewise, auditory hair cells have highly reproducible rows …

The morphology and structure of the intestinal epithelium are rearranged dynamically during
development, tissue regeneration, and disease progression. The most important …

The delivery of intracellular material within cells is crucial for maintaining normal function.
Myosins transport a wide variety of cargo, ranging from vesicles to ribonuclear protein …

Microvilli are a common structure found on epithelial cells that increase the apical surface
thus enhancing the transmembrane transport capacity and also serve as one of the cell's …