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The emergence and evolution of SARS-CoV-2
EC Holmes - Annual review of virology, 2024 - annualreviews.org
The origin of SARS-CoV-2 has evoked heated debate and strong accusations, yet
seemingly little resolution. I review the scientific evidence on the origin of SARS-CoV-2 and …
seemingly little resolution. I review the scientific evidence on the origin of SARS-CoV-2 and …
Animal models of Long Covid: A hit-and-run disease
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) pandemic has caused
more than 7 million deaths globally. Despite the presence of infection-and vaccine-induced …
more than 7 million deaths globally. Despite the presence of infection-and vaccine-induced …
The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo
The COVID-19 pandemic has led to the deaths of millions of people and severe global
economic impacts. Small molecule therapeutics have played an important role in the fight …
economic impacts. Small molecule therapeutics have played an important role in the fight …
Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination
We describe the molecular-level composition of polyclonal immunoglobulin G (IgG) anti-
spike antibodies from ancestral severe acute respiratory syndrome coronavirus 2 (SARS …
spike antibodies from ancestral severe acute respiratory syndrome coronavirus 2 (SARS …
[HTML][HTML] Genetic loci regulate Sarbecovirus pathogenesis: A comparison across mice and humans
Coronavirus (CoV) cause considerable morbidity and mortality in humans and other
mammals, as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in …
mammals, as evidenced by the emergence of Severe Acute Respiratory CoV (SARS-CoV) in …
An oral non-covalent non-peptidic inhibitor of SARS-CoV-2 Mpro ameliorates viral replication and pathogenesis in vivo
Safe, effective, and low-cost oral antiviral therapies are needed to treat those at high risk for
develo** severe COVID-19. To that end, we performed a high-throughput screen to …
develo** severe COVID-19. To that end, we performed a high-throughput screen to …
Vaccine-mediated protection against Merbecovirus and Sarbecovirus challenge in mice
The emergence of three highly pathogenic human coronaviruses—severe acute respiratory
syndrome coronavirus (SARS-CoV) in 2003, Middle Eastern respiratory syndrome (MERS) …
syndrome coronavirus (SARS-CoV) in 2003, Middle Eastern respiratory syndrome (MERS) …
[HTML][HTML] A Comparative Experimental and Computational Study on the Nature of the Pangolin-CoV and COVID-19 Omicron
The relationship between pangolin-CoV and SARS-CoV-2 has been a subject of debate.
Further evidence of a special relationship between the two viruses can be found by the fact …
Further evidence of a special relationship between the two viruses can be found by the fact …
Will releasing the weights of future large language models grant widespread access to pandemic agents?
A Gopal, N Helm-Burger, L Justen, EH Soice… - arxiv preprint arxiv …, 2023 - arxiv.org
Large language models can benefit research and human understanding by providing
tutorials that draw on expertise from many different fields. A properly safeguarded model will …
tutorials that draw on expertise from many different fields. A properly safeguarded model will …
A trivalent mucosal vaccine encoding phylogenetically inferred ancestral RBD sequences confers pan-Sarbecovirus protection in mice
The continued emergence of SARS-CoV-2 variants and the threat of future Sarbecovirus
zoonoses have spurred the design of vaccines that can induce broad immunity against …
zoonoses have spurred the design of vaccines that can induce broad immunity against …