Osteoarthritis genetics has been transformed in the past decade through the application of
large-scale genome-wide association scans. So far, over 100 polymorphic DNA variants …

Research into the molecular genetics of osteoarthritis (OA) has been substantially bolstered
in the past few years by the implementation of powerful genome-wide scans that have …

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide
association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and …

Although osteoarthritis (OA) aetiology is complex, genetic, genomic and epigenetic studies
published within the last decade have advanced our understanding of the molecular …

Mammalian E3 ubiquitin ligases have emerged in recent years as critical regulators of
cellular homeostasis due to their roles in targeting substrate proteins for ubiquitination and …

Objective To elucidate the scientific advances made in the last 12 months within the realm of
osteoarthritis genetics, genomics, and epigenetics. This review paper highlights major …

Osteoarthritis (OA) is a polygenic disease of older people resulting in the breakdown of
cartilage within articular joints. Although it is a leading cause of disability, there are no …

Background Failing of intrinsic chondrocyte repair after mechanical stress is known as one
of the most important initiators of osteoarthritis. Nonetheless, insight into these early …

Background Despite recent advances in the understanding of the genetic architecture of
osteoarthritis (OA), only two genetic loci have been identified for OA of the hand, in part …

Cytokines and their receptors have a vital function in regulating various processes such as
immune function, inflammation, haematopoiesis, cell growth and differentiation. The …