Microbiome and human health: current understanding, engineering, and enabling technologies

N Aggarwal, S Kitano, GRY Puah, S Kittelmann… - Chemical …, 2022 - ACS Publications
The human microbiome is composed of a collection of dynamic microbial communities that
inhabit various anatomical locations in the body. Accordingly, the coevolution of the …

Immune responses to human fungal pathogens and therapeutic prospects

MS Lionakis, RA Drummond, TM Hohl - Nature Reviews Immunology, 2023 - nature.com
Pathogenic fungi have emerged as significant causes of infectious morbidity and death in
patients with acquired immunodeficiency conditions such as HIV/AIDS and following receipt …

[HTML][HTML] The gut mycobiome in health, disease, and clinical applications in association with the gut bacterial microbiome assembly

F Zhang, D Aschenbrenner, JY Yoo, T Zuo - The Lancet Microbe, 2022 - thelancet.com
The gut mycobiome (fungi) is a small but crucial component of the gut microbiome in
humans. Intestinal fungi regulate host homoeostasis, pathophysiological and physiological …

[HTML][HTML] Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity

I Leonardi, IH Gao, WY Lin, M Allen, XV Li, WD Fiers… - Cell, 2022 - cell.com
Fungal communities (the mycobiota) are an integral part of the gut microbiota, and the
disruption of their integrity contributes to local and gut-distal pathologies. Yet, the …

Inflammatory bowel diseases (IBD) and the microbiome—searching the crime scene for clues

M Lee, EB Chang - Gastroenterology, 2021 - Elsevier
Inflammatory bowel diseases (IBD) develop via convergence of environmental, microbial,
immunological, and genetic factors. Alterations in the gut microbiota have been associated …

Interaction between microbiota and immunity in health and disease

D Zheng, T Liwinski, E Elinav - Cell research, 2020 - nature.com
The interplay between the commensal microbiota and the mammalian immune system
development and function includes multifold interactions in homeostasis and disease. The …

Immune regulation by fungal strain diversity in inflammatory bowel disease

XV Li, I Leonardi, GG Putzel, A Semon, WD Fiers… - Nature, 2022 - nature.com
The fungal microbiota (mycobiota) is an integral part of the complex multikingdom microbial
community colonizing the mammalian gastrointestinal tract and has an important role in …

The microbiome and inflammatory bowel disease

KL Glassner, BP Abraham, EMM Quigley - Journal of Allergy and Clinical …, 2020 - Elsevier
Inflammatory bowel disease (IBD) is a chronic immune-mediated disease affecting the
gastrointestinal tract. IBD consists of 2 subtypes: ulcerative colitis and Crohn disease. IBD is …

Pathway paradigms revealed from the genetics of inflammatory bowel disease

DB Graham, RJ Xavier - Nature, 2020 - nature.com
Inflammatory bowel disease (IBD) is a complex genetic disease that is instigated and
amplified by the confluence of multiple genetic and environmental variables that perturb the …

Translocation of viable gut microbiota to mesenteric adipose drives formation of cree** fat in humans

CWY Ha, A Martin, GD Sepich-Poore, B Shi, Y Wang… - Cell, 2020 - cell.com
A mysterious feature of Crohn's disease (CD) is the extra-intestinal manifestation of"
cree** fat"(CrF), defined as expansion of mesenteric adipose tissue around the inflamed …