Pituitary crosstalk with bone, adipose tissue and brain

M Zaidi, T Yuen, SM Kim - Nature Reviews Endocrinology, 2023 - nature.com
Traditional textbook physiology has ascribed unitary functions to hormones from the anterior
and posterior pituitary gland, mainly in the regulation of effector hormone secretion from …

Emerging roles of brain tanycytes in regulating blood–hypothalamus barrier plasticity and energy homeostasis

H Kannangara, L Cullen, S Miyashita… - Annals of the New …, 2023 - Wiley Online Library
Seasonal changes in food intake and adiposity in many animal species are triggered by
changes in the photoperiod. These latter changes are faithfully transduced into a …

Gene–dose-dependent reduction of Fshr expression improves spatial memory deficits in Alzheimer's mice

F Korkmaz, S Sims, F Sen, F Sultana, V Laurencin… - Molecular …, 2024 - nature.com
High post-menopausal levels of the pituitary gonadotropin follicle-stimulating hormone
(FSH) are strongly associated with the onset of Alzheimer's disease (AD). We have shown …

Regulation of thyroid hormone gatekeepers by thyrotropin in tanycytes

A Chandrasekar, PM Schmidtlein, V Neve… - Thyroid, 2024 - liebertpub.com
Background: Tanycytes are specialized glial cells within the mediobasal hypothalamus that
have multiple functions, including hormone sensing and regulation of hypophysiotropic …

Neuroendocrinology of bone

SM Kim, F Sultana, F Korkmaz, S Rojekar, A Pallapati… - Pituitary, 2024 - Springer
The past decade has witnessed significant advances in our understanding of skeletal
homeostasis and the mechanisms that mediate the loss of bone in primary and secondary …

Absent LH signaling rescues the anxiety phenotype in aging female mice

S Sims, O Barak, V Ryu, S Miyashita… - Molecular …, 2023 - nature.com
Clinical studies and experimental data together support a role for pituitary gonadotropins,
including luteinizing hormone (LH), otherwise considered solely as fertility hormones, in age …

FSH, bone, belly and brain

SM Kim, F Sultana, S Sims… - Journal of …, 2024 - joe.bioscientifica.com
The pituitary gland orchestrates multiple endocrine organs by secreting tropic hormones,
and therefore plays a significant role in a myriad of physiological processes, including …

Follicle-stimulating hormone: More than a marker for menopause FSH as a frontier for women's mental health

J Spicer, D Malaspina, SV Blank, KA Goosens - Psychiatry Research, 2024 - Elsevier
The average current life expectancy entails that women will spend over one third of their
lives in menopause. Follicle-stimulating hormone (FSH) levels in women begin to increase …

Therapeutic benefits of central LH receptor agonism in the APP/PS1 AD model involve trophic and immune regulation and are reproductive status dependent

M Mey, S Bhatta, S Suresh, LM Labrador… - … et Biophysica Acta (BBA …, 2024 - Elsevier
The mechanisms that underly reproductive hormone effects on cognition, neuronal plasticity,
and AD risk, particularly in relation to gonadotropin LH receptor (LHCGR) signaling, remain …

The influence of extended fasting on thyroid hormone: local and differentiated regulatory mechanisms

X Sui, S Jiang, H Zhang, F Wu, H Wang… - Frontiers in …, 2024 - frontiersin.org
The hypometabolism induced by fasting has great potential in maintaining health and
improving survival in extreme environments, among which thyroid hormone (TH) plays an …