Recent evidence indicates that sensory and motor changes may precede the cognitive
symptoms of Alzheimer's disease (AD) by several years and may signify increased risk of …

Abstract Introduction The World Health Organization has introduced the term 'intrinsic
capacity'(IC) as a marker of healthy ageing. However, controversy exists on the definition …

The ability to investigate therapeutic interventions in animal models of neurodegenerative
diseases depends on extensive characterization of the model (s) being used. There are …

The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort
study of common chronic conditions of aging with an emphasis on decline in cognitive and …

Gait assessment is an essential tool for clinical applications not only to diagnose different
neurological conditions but also to monitor disease progression as it contributes to the …

Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are highly prevalent
conditions with growing impact on our aging society. While the causes of OSA are now …

Neurodegenerative disorders (NDs) affect essential functions not only in the CNS, but also
cause persistent gut dysfunctions, suggesting that they have an impact on both CNS and gut …

Abstract Background The Montreal Cognitive Assessment (MoCA) is known to have
discriminative power for patients with Mild Cognitive Impairment (MCI). Recently Cognitive …

Building upon the recent advances and successes in the application of deep learning to the
medical field, we propose in this work a new approach to detect and classify early-stage …

Objectives Factors that are responsible for age-related neurologic deterioration of
noncognitive and cognitive processes may have a shared cause. We sought to examine the …