AGC protein kinases: from structural mechanism of regulation to allosteric drug development for the treatment of human diseases
JM Arencibia, D Pastor-Flores, AF Bauer… - … et Biophysica Acta (BBA …, 2013 - Elsevier
The group of AGC protein kinases includes more than 60 protein kinases in the human
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …
The role of intestinal oxalate transport in hyperoxaluria and the formation of kidney stones in animals and man
JM Whittamore, M Hatch - Urolithiasis, 2017 - Springer
The intestine exerts a considerable influence over urinary oxalate in two ways, through the
absorption of dietary oxalate and by serving as an adaptive extra-renal pathway for …
absorption of dietary oxalate and by serving as an adaptive extra-renal pathway for …
DNA variations in oculocutaneous albinism: an updated mutation list and current outstanding issues in molecular diagnostics
DR Simeonov, X Wang, C Wang, Y Sergeev… - Human …, 2013 - Wiley Online Library
Oculocutaneous albinism (OCA) is a rare genetic disorder of melanin synthesis that results
in hypopigmented hair, skin, and eyes. There are four types of OCA caused by mutations in …
in hypopigmented hair, skin, and eyes. There are four types of OCA caused by mutations in …
The ovarian cycle
JAS Richards - Vitamins and hormones, 2018 - Elsevier
The “ovarian cycle” is an exquisite and dynamic endocrine system that includes ovarian
events, hypothalamic–pituitary interactions, uterine endometrial and myometrial changes …
events, hypothalamic–pituitary interactions, uterine endometrial and myometrial changes …
[HTML][HTML] Calcium-based biomaterials: Unveiling features and expanding applications in osteosarcoma treatment
Y Wu, M Cheng, Y Jiang, X Zhang, J Li, Y Zhu, Q Yao - Bioactive Materials, 2024 - Elsevier
Calcium, an indispensable element in bone tissues, plays a crucial role in various cellular
processes involved in cancer progression. Its ubiquitous yet spatially distinct distribution in …
processes involved in cancer progression. Its ubiquitous yet spatially distinct distribution in …
EMP1, EMP 2, and EMP3 as novel therapeutic targets in human cancer
YW Wang, HL Cheng, YR Ding, LH Chou… - Biochimica et Biophysica …, 2017 - Elsevier
The epithelial membrane protein genes 1, 2, and 3 (EMP1, EMP2, and EMP3) belong to the
peripheral myelin protein 22-kDa (PMP22) gene family, which consists of at least seven …
peripheral myelin protein 22-kDa (PMP22) gene family, which consists of at least seven …
Upstream and Downstream Pathways of Diacylglycerol Kinase Novel Phosphatidylinositol Turnover-independent Signal Transduction Pathways
Diacylglycerol kinase (DGK) phosphorylates diacylglycerol (DG) to produce phosphatidic
acid (PA). Mammalian DGK comprise ten isozymes (α–κ) that regulate a wide variety of …
acid (PA). Mammalian DGK comprise ten isozymes (α–κ) that regulate a wide variety of …
Regulation of paracellular permeability: factors and mechanisms
YJ Hu, YD Wang, FQ Tan, WX Yang - Molecular biology reports, 2013 - Springer
Epithelial permeability is composed of transcellular permeability and paracellular
permeability. Paracellular permeability is controlled by tight junctions (TJs). Claudins and …
permeability. Paracellular permeability is controlled by tight junctions (TJs). Claudins and …
Astragaloside IV inhibits migration and invasion in human lung cancer A549 cells via regulating PKC-α-ERK1/2-NF-κB pathway
X Cheng, J Gu, M Zhang, J Yuan, B Zhao… - International …, 2014 - Elsevier
The migration and invasion characteristics that are related to inflammatory response play
important roles in the development of lung cancer. Astagaloside IV (AS-IV), an effective …
important roles in the development of lung cancer. Astagaloside IV (AS-IV), an effective …
Kinase-dependent regulation of monoamine neurotransmitter transporters
Modulation of neurotransmission by the monoamines dopamine (DA), norepinephrine (NE),
and serotonin (5-HT) is critical for normal nervous system function. Precise temporal and …
and serotonin (5-HT) is critical for normal nervous system function. Precise temporal and …