Amplification-free CRISPR/Cas detection technology: challenges, strategies, and perspectives

H Li, Y **e, F Chen, H Bai, L **u, X Zhou… - Chemical Society …, 2023 - pubs.rsc.org
Rapid and accurate molecular diagnosis is a prerequisite for precision medicine, food
safety, and environmental monitoring. The clustered regularly interspaced short palindromic …

Functionalizing framework nucleic‐acid‐based nanostructures for biomedical application

T Zhang, T Tian, Y Lin - Advanced Materials, 2022 - Wiley Online Library
Strategies for functionalizing diverse tetrahedral framework nucleic acids (tFNAs) have been
extensively explored since the first successful fabrication of tFNA by Turberfield. One‐pot …

Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples

L Wang, X Wang, Y Wu, M Guo, C Gu, C Dai… - Nature Biomedical …, 2022 - nature.com
The detection of samples at ultralow concentrations (one to ten copies in 100 μl) in biofluids
is hampered by the orders-of-magnitude higher amounts of 'background'biomolecules. Here …

DNA-framework-based multidimensional molecular classifiers for cancer diagnosis

F Yin, H Zhao, S Lu, J Shen, M Li, X Mao, F Li… - Nature …, 2023 - nature.com
A molecular classification of diseases that accurately reflects clinical behaviour lays the
foundation of precision medicine. The development of in silico classifiers coupled with …

2D semiconductors for specific electronic applications: from device to system

X Huang, C Liu, P Zhou - npj 2D Materials and Applications, 2022 - nature.com
The shrinking of transistors has hit a wall of material degradation and the specialized
electronic applications for complex scenarios have raised challenges in heterostructures …

Design, fabrication and applications of tetrahedral DNA nanostructure-based multifunctional complexes in drug delivery and biomedical treatment

T Zhang, T Tian, R Zhou, S Li, W Ma, Y Zhang, N Liu… - Nature protocols, 2020 - nature.com
Although organic nanomaterials and inorganic nanoparticles possess inherent flexibility,
facilitating functional modification, increased intracellular uptake and controllable drug …

Nucleic acid tests for clinical translation

M Li, F Yin, L Song, X Mao, F Li, C Fan, X Zuo… - Chemical …, 2021 - ACS Publications
Nucleic acids, including deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), are
natural biopolymers composed of nucleotides that store, transmit, and express genetic …

DNA walkers for biosensing development

L Song, Y Zhuge, X Zuo, M Li, F Wang - Advanced Science, 2022 - Wiley Online Library
The ability to design nanostructures with arbitrary shapes and controllable motions has
made DNA nanomaterials used widely to construct diverse nanomachines with various …

Isothermal amplification of nucleic acids

Y Zhao, F Chen, Q Li, L Wang, C Fan - Chemical reviews, 2015 - ACS Publications
Isothermal amplification of nucleic acids is a simple process that rapidly and efficiently
accumulates nucleic acid sequences at constant temperature. Since the early 1990s …

Biomolecular sensors for advanced physiological monitoring

CD Flynn, D Chang, A Mahmud, H Yousefi… - Nature Reviews …, 2023 - nature.com
Body-based biomolecular sensing systems, including wearable, implantable and
consumable sensors allow comprehensive health-related monitoring. Glucose sensors have …