In recent years, tumor immunotherapy has made significant progress. However, tumor
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …

Sepsis is a life-threatening clinical syndrome caused by infection. Its pathogenesis is
complex and entails coagulation dysfunction, inflammation, and immune disorders …

Host microbial cross-talk is essential to maintain intestinal homeostasis. However,
maladaptation of this response through microbial dysbiosis or defective host defense toward …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Lactate is an end product of glycolysis. As a critical energy source for mitochondrial
respiration, lactate also acts as a precursor of gluconeogenesis and a signaling molecule …

In the gastro-intestinal tract, short chain fatty acids (SCFAs) have protective effects on
epithelial cells. However, their effects on inflammatory cytokine production by endothelial …

Macrophages are key cellular components of the innate immunity, acting as the main player
in the first‐line defence against the pathogens and modulating homeostatic and …

Gut dysbiosis might underlie the pathogenesis of type 1 diabetes. In mice of the non-obese
diabetic (NOD) strain, we found that key features of disease correlated inversely with blood …

Recent clinical trials have demonstrated the ability to durably control cancer in some
patients by manipulating T lymphocytes. These immunotherapies are revolutionizing cancer …

Rationale: It is known that neuroinflammation plays a critical and detrimental role in the
development of cerebral ischemia/reperfusion (I/R), but the regulation of the cyclic GMP …