Nanopores: A journey towards DNA sequencing

M Wanunu - Physics of life reviews, 2012 - Elsevier
Much more than ever, nucleic acids are recognized as key building blocks in many of lifeʼs
processes, and the science of studying these molecular wonders at the single-molecule …

The application of single molecule nanopore sensing for quantitative analysis

Y Wu, JJ Gooding - Chemical Society Reviews, 2022 - pubs.rsc.org
Nanopore-based sensors typically work by monitoring transient pulses in conductance via
current–time traces as molecules translocate through the nanopore. The unique property of …

Nanopore-based protein identification

M Afshar Bakshloo, JJ Kasianowicz… - Journal of the …, 2022 - ACS Publications
The implementation of a reliable, rapid, inexpensive, and simple method for whole-proteome
identification would greatly benefit cell biology research and clinical medicine. Proteins are …

Electrochemical sensors

E Bakker, M Telting-Diaz - Analytical chemistry, 2002 - ACS Publications
The last fundamental review on this general topic was entitled Dynamic Electrochemistry
and diverted significantly from the earlier series on chemical sensors by Janata in scope and …

Nanopore analytics: sensing of single molecules

S Howorka, Z Siwy - Chemical Society Reviews, 2009 - pubs.rsc.org
In nanopore analytics, individual molecules pass through a single nanopore giving rise to
detectable temporary blockades in ionic pore current. Reflecting its simplicity, nanopore …

Nanoelectrochemistry: metal nanoparticles, nanoelectrodes, and nanopores

RW Murray - Chemical reviews, 2008 - ACS Publications
Nano-is a big prefix-word. Much of contemporary chemistry focuses on small scale
structures, and indeed, molecular science is intrinsically on the nanometer scale. Selecting …

Digitally encoded DNA nanostructures for multiplexed, single-molecule protein sensing with nanopores

NAW Bell, UF Keyser - Nature nanotechnology, 2016 - nature.com
The simultaneous detection of a large number of different analytes is important in
bionanotechnology research and in diagnostic applications. Nanopore sensing is an …

DNA molecules and configurations in a solid-state nanopore microscope

J Li, M Gershow, D Stein, E Brandin… - Nature materials, 2003 - nature.com
A nanometre-scale pore in a solid-state membrane provides a new way of electronically
probing the structure of single linear polymers, including those of biological interest in their …

Single-nucleotide discrimination in immobilized DNA oligonucleotides with a biological nanopore

D Stoddart, AJ Heron, E Mikhailova… - Proceedings of the …, 2009 - National Acad Sciences
The sequencing of individual DNA strands with nanopores is under investigation as a rapid,
low-cost platform in which bases are identified in order as the DNA strand is transported …

Imaging α-hemolysin with molecular dynamics: ionic conductance, osmotic permeability, and the electrostatic potential map

A Aksimentiev, K Schulten - Biophysical journal, 2005 - cell.com
Abstract α-Hemolysin of Staphylococcus aureus is a self-assembling toxin that forms a water-
filled transmembrane channel upon oligomerization in a lipid membrane. Apart from being …