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Pulmonary surfactant: a mighty thin film
Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …
Hydrophobic surfactant proteins in lung function and disease
JA Whitsett, TE Weaver - New England Journal of Medicine, 2002 - Mass Medical Soc
Pulmonary surfactants consist of phospholipids and the hydrophobic proteins surfactant
protein B and surfactant protein C. These surfactants keep the alveoli in the lung open to the …
protein B and surfactant protein C. These surfactants keep the alveoli in the lung open to the …
Aqueous phase polymeric corrosion inhibitors: Recent advancements and future opportunities
The use of heterocyclic compounds is established as one of the most successful, economic
and practical techniques of corrosion protection. The heterocyclic compounds develop into …
and practical techniques of corrosion protection. The heterocyclic compounds develop into …
Function of surfactant proteins B and C
TE Weaver, JJ Conkright - Annual review of physiology, 2001 - annualreviews.org
▪ Abstract SP-B is the only surfactant-associated protein absolutely required for postnatal
lung function and survival. Complete deficiency of SP-B in mice and humans results in …
lung function and survival. Complete deficiency of SP-B in mice and humans results in …
Genetic disorders of surfactant dysfunction
SE Wert, JA Whitsett, LM Nogee - Pediatric and …, 2009 - journals.sagepub.com
Mutations in the genes encoding the surfactant proteins B and C (SP-B and SP-C) and the
phospholipid transporter, ABCA3, are associated with respiratory distress and interstitial …
phospholipid transporter, ABCA3, are associated with respiratory distress and interstitial …
An overview of pulmonary surfactant in the neonate: genetics, metabolism, and the role of surfactant in health and disease
PO Nkadi, TA Merritt, DAM Pillers - Molecular genetics and metabolism, 2009 - Elsevier
Pulmonary surfactant is a complex mixture of phospholipids (PL) and proteins (SP) that
reduce surface tension at the air–liquid interface of the alveolus. It is made up of about 70 …
reduce surface tension at the air–liquid interface of the alveolus. It is made up of about 70 …
Altered stability of pulmonary surfactant in SP-C-deficient mice
SW Glasser, MS Burhans, TR Korfhagen, CL Na… - Proceedings of the …, 2001 - pnas.org
The surfactant protein C (SP-C) gene encodes an extremely hydrophobic, 4-kDa peptide
produced by alveolar epithelial cells in the lung. To discern the role of SP-C in lung function …
produced by alveolar epithelial cells in the lung. To discern the role of SP-C in lung function …
A surfactant protein C precursor protein BRICHOS domain mutation causes endoplasmic reticulum stress, proteasome dysfunction, and caspase 3 activation
S Mulugeta, V Nguyen, SJ Russo… - American journal of …, 2005 - atsjournals.org
BRICHOS is a domain found in several proteins consisting of∼ 100 amino acids with
sequence and structural similarities. Mutations in BRICHOS domain have been associated …
sequence and structural similarities. Mutations in BRICHOS domain have been associated …
Interfacial properties of pulmonary surfactant layers
The composition of the pulmonary surfactant and the border conditions of normal human
breathing are relevant to characterize the interfacial behavior of pulmonary layers. Based on …
breathing are relevant to characterize the interfacial behavior of pulmonary layers. Based on …
Alterations in SP-B and SP-C expression in neonatal lung disease
LM Nogee - Annual Review of Physiology, 2004 - search.proquest.com
The hydrophobic surfactant proteins, SP-B and SP-C, have important roles in surfactant
function. The importance of these proteins in normal lung function is highlighted by the lung …
function. The importance of these proteins in normal lung function is highlighted by the lung …