Pulmonary surfactant: a mighty thin film

F Possmayer, YY Zuo, RAW Veldhuizen… - Chemical …, 2023 - ACS Publications
Pulmonary surfactant is a critical component of lung function in healthy individuals. It
functions in part by lowering surface tension in the alveoli, thereby allowing for breathing …

Hydrophobic surfactant proteins in lung function and disease

JA Whitsett, TE Weaver - New England Journal of Medicine, 2002 - Mass Medical Soc
Pulmonary surfactants consist of phospholipids and the hydrophobic proteins surfactant
protein B and surfactant protein C. These surfactants keep the alveoli in the lung open to the …

Aqueous phase polymeric corrosion inhibitors: Recent advancements and future opportunities

C Verma, MA Quraishi, KY Rhee - Journal of Molecular Liquids, 2022 - Elsevier
The use of heterocyclic compounds is established as one of the most successful, economic
and practical techniques of corrosion protection. The heterocyclic compounds develop into …

Function of surfactant proteins B and C

TE Weaver, JJ Conkright - Annual review of physiology, 2001 - annualreviews.org
▪ Abstract SP-B is the only surfactant-associated protein absolutely required for postnatal
lung function and survival. Complete deficiency of SP-B in mice and humans results in …

Genetic disorders of surfactant dysfunction

SE Wert, JA Whitsett, LM Nogee - Pediatric and …, 2009 - journals.sagepub.com
Mutations in the genes encoding the surfactant proteins B and C (SP-B and SP-C) and the
phospholipid transporter, ABCA3, are associated with respiratory distress and interstitial …

An overview of pulmonary surfactant in the neonate: genetics, metabolism, and the role of surfactant in health and disease

PO Nkadi, TA Merritt, DAM Pillers - Molecular genetics and metabolism, 2009 - Elsevier
Pulmonary surfactant is a complex mixture of phospholipids (PL) and proteins (SP) that
reduce surface tension at the air–liquid interface of the alveolus. It is made up of about 70 …

Altered stability of pulmonary surfactant in SP-C-deficient mice

SW Glasser, MS Burhans, TR Korfhagen, CL Na… - Proceedings of the …, 2001 - pnas.org
The surfactant protein C (SP-C) gene encodes an extremely hydrophobic, 4-kDa peptide
produced by alveolar epithelial cells in the lung. To discern the role of SP-C in lung function …

A surfactant protein C precursor protein BRICHOS domain mutation causes endoplasmic reticulum stress, proteasome dysfunction, and caspase 3 activation

S Mulugeta, V Nguyen, SJ Russo… - American journal of …, 2005 - atsjournals.org
BRICHOS is a domain found in several proteins consisting of∼ 100 amino acids with
sequence and structural similarities. Mutations in BRICHOS domain have been associated …

Interfacial properties of pulmonary surfactant layers

R Wüstneck, J Perez-Gil, N Wüstneck, A Cruz… - Advances in colloid and …, 2005 - Elsevier
The composition of the pulmonary surfactant and the border conditions of normal human
breathing are relevant to characterize the interfacial behavior of pulmonary layers. Based on …

Alterations in SP-B and SP-C expression in neonatal lung disease

LM Nogee - Annual Review of Physiology, 2004 - search.proquest.com
The hydrophobic surfactant proteins, SP-B and SP-C, have important roles in surfactant
function. The importance of these proteins in normal lung function is highlighted by the lung …