[HTML][HTML] Impact of heavy metals on the environment and human health: Novel therapeutic insights to counter the toxicity

S Mitra, AJ Chakraborty, AM Tareq, TB Emran… - Journal of King Saud …, 2022 - Elsevier
Heavy metals are well-known environmental pollutants owing to their toxicity, longevity in
the atmosphere, and ability to accumulate in the human body via bioaccumulation. The …

Piperine: A review of its biological effects

IU Haq, M Imran, M Nadeem, T Tufail… - Phytotherapy …, 2021 - Wiley Online Library
Medicinal plants have been used for years as a source of food, spices, and, in traditional
medicine, as a remedy to numerous diseases. Piper nigrum, belonging to the family …

[HTML][HTML] Piperine-a major principle of black pepper: a review of its bioactivity and studies

Z Stojanović-Radić, M Pejčić, M Dimitrijević, A Aleksić… - Applied Sciences, 2019 - mdpi.com
Piperine is the main compound present in black pepper, and is the carrier of its specific
pungent taste, which is responsible for centuries of human dietary utilization and worldwide …

Preparation, pungency and bioactivity transduction of piperine from black pepper (piper nigrum L.): a comprehensive review

R Zou, Y Zhou, Y Lu, Y Zhao, N Zhang, J Liu, Y Zhang… - Food Chemistry, 2024 - Elsevier
Piperine, derived from black pepper (Piper nigrum L.), is responsible for the pungent
sensation. The diverse bioactivities of piperine underscores its promising potential as a …

Synergistic Effects of Curcumin and Piperine as Potent Acetylcholine and Amyloidogenic Inhibitors With Significant Neuroprotective Activity in SH-SY5Y Cells via Computational …

AS Abdul Manap, AC Wei Tan, WH Leong… - Frontiers in aging …, 2019 - frontiersin.org
Hallmarks of Alzheimer's disease (AD) pathology include acetylcholine (ACh) deficiency and
plaque deposition. Emerging studies suggest that acetylcholinesterase (AChE) may interact …

Piperine: old spice and new nutraceutical?

K Smilkov, DG Ackova, A Cvetkovski… - Current …, 2019 - benthamdirect.com
Background: Many of the activities associated with pepper fruits have been attributed to
piperine, the most active compound present in these spices. Objective: This paper aims to …

Cardiovascular protective effect of black pepper (Piper nigrum L.) and its major bioactive constituent piperine

D Wang, L Zhang, J Huang, K Himabindu… - Trends in food science & …, 2021 - Elsevier
Abstract Background Cardiovascular diseases (CVDs) are the leading cause of death
worldwide. Black pepper, the fruits of Piper nigrum L., is well known as “the king of spices” …

A review on the bioavailability, bio-efficacies and novel delivery systems for piperine

W Zhang, Q Zheng, M Song, J **ao, Y Cao, Q Huang… - Food & Function, 2021 - pubs.rsc.org
As the major naturally occurring alkaloid in pepper with a pungent taste, piperine is known
for its beneficial biological functions and therapeutic effects. In this work, the bioavailability …

GC–MS fingerprinting, nutritional composition, in vitro pharmacological activities and molecular docking studies of Piper chaba from Uttarakhand region

V Joshi, V Bachhar, SS Mishra, RK Shukla, A Gangal… - 3 Biotech, 2024 - Springer
This study aimed to evaluate the potential therapeutic effects of Piper chaba (PC) growing in
the northern region of India, having differences in the phytochemicals, nutritional content …

[HTML][HTML] Piperine inhibits TGF-β signaling pathways and disrupts EMT-related events in human lung adenocarcinoma cells

L Marques da Fonseca, LR Jacques da Silva… - Medicines, 2020 - mdpi.com
Background: Piperine, an amide extracted from the Piper spices, exhibits strong anti-tumor
properties. However, its effect on the epithelial–mesenchymal transition (EMT) process has …