Development by self-digestion: molecular mechanisms and biological functions of autophagy
Autophagy is the major cellular pathway for the degradation of long-lived proteins and
cytoplasmic organelles. It involves the rearrangement of subcellular membranes to …
cytoplasmic organelles. It involves the rearrangement of subcellular membranes to …
The emerging field of lipidomics
MR Wenk - Nature reviews Drug discovery, 2005 - nature.com
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large
number of genetic studies and by many human diseases that involve the disruption of lipid …
number of genetic studies and by many human diseases that involve the disruption of lipid …
PI3K in lymphocyte development, differentiation and activation
Abstract Phosphoinositide 3-kinases (PI3Ks) regulate numerous biological processes,
including cell growth, differentiation, survival, proliferation, migration and metabolism. In the …
including cell growth, differentiation, survival, proliferation, migration and metabolism. In the …
Clathrin-and non-clathrin-mediated endocytic regulation of cell signalling
C Le Roy, JL Wrana - Nature reviews Molecular cell biology, 2005 - nature.com
The internalization of various cargo proteins and lipids from the mammalian cell surface
occurs through the clathrin and lipid-raft endocytic pathways. Protein–lipid and protein …
occurs through the clathrin and lipid-raft endocytic pathways. Protein–lipid and protein …
PIP2 and Proteins: Interactions, Organization, and Information Flow
S McLaughlin, J Wang, A Gambhir… - Annual review of …, 2002 - annualreviews.org
▪ Abstract We review the physical properties of phosphatidylinositol 4, 5-bisphosphate (PIP2)
that determine both its specific interactions with protein domains of known structure and its …
that determine both its specific interactions with protein domains of known structure and its …
Plasma membrane phosphoinositide organization by protein electrostatics
S McLaughlin, D Murray - Nature, 2005 - nature.com
Abstract Phosphatidylinositol 4, 5-bisphosphate (PIP2), which comprises only about 1% of
the phospholipids in the cytoplasmic leaflet of the plasma membrane, is the source of three …
the phospholipids in the cytoplasmic leaflet of the plasma membrane, is the source of three …
Rab7 is required for the normal progression of the autophagic pathway in mammalian cells
MG Gutierrez, DB Munafó, W Berón… - Journal of cell …, 2004 - journals.biologists.com
Autophagy is a normal degradative pathway that involves the sequestration of cytoplasmic
components and organelles in a vacuole called an autophagosome that finally fuses with …
components and organelles in a vacuole called an autophagosome that finally fuses with …
The endocytic pathway: a mosaic of domains
J Gruenberg - Nature reviews Molecular cell biology, 2001 - nature.com
Organelles in the endocytic pathway are composed of a mosaic of structural and functional
regions. These regions consist, at least in part, of specialized protein–lipid domains within …
regions. These regions consist, at least in part, of specialized protein–lipid domains within …
Signaling by the phosphoinositide 3-kinase family in immune cells
K Okkenhaug - Annual review of immunology, 2013 - annualreviews.org
Phosphoinositide 3-kinases (PI3Ks) control many important aspects of immune cell
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …
Molecular architecture and functional model of the endocytic AP2 complex
AP2 is the best-characterized member of the family of heterotetrameric clathrin adaptor
complexes that play pivotal roles in many vesicle trafficking pathways within the cell. AP2 …
complexes that play pivotal roles in many vesicle trafficking pathways within the cell. AP2 …