Ferroptosis, a newly emerged form of regulated necrotic cell death, has been demonstrated
to play an important role in multiple diseases including cancer, neurodegeneration, and …

Pre-mRNA alternative splicing is a prevalent mechanism for diversifying eukaryotic
transcriptomes and proteomes. Regulated alternative splicing plays a role in many …

Resolving the spatial distribution of RNA and protein in tissues at subcellular resolution is a
challenge in the field of spatial biology. We describe spatial molecular imaging, a system …

Ferroptosis is a mode of regulated cell death characterized by iron-dependent accumulation
of lipid peroxidation. It is closely linked to the pathophysiological processes in many …

Broad-spectrum RAS inhibition has the potential to benefit roughly a quarter of human
patients with cancer whose tumours are driven by RAS mutations,. RMC-7977 is a highly …

Lactate has long been considered a cellular waste product. However, we found that as
extracellular lactate accumulates, it also enters the mitochondrial matrix and stimulates …

The YAP–TEAD protein–protein interaction mediates YAP oncogenic functions downstream
of the Hippo pathway. To date, available YAP–TEAD pharmacologic agents bind into the …

Aggressive and metastatic cancers show enhanced metabolic plasticity, but the precise
underlying mechanisms of this remain unclear. Here we show how two NOP2/Sun RNA …

Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion
and resistance to therapy. Here, using paired whole-exome and RNA sequencing data, we …

In contrast to normal type I collagen (Col1) heterotrimer (α1/α2/α1) produced by fibroblasts,
pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 …