In the late 19th century, formalin fixation with paraffin-embedding (FFPE) of tissues was
developed as a fixation and conservation method and is still used to this day in routine …

Abstract 1α, 25-Dihydroxyvitamin D3 signals via the vitamin D receptor (VDR). Higher serum
vitamin D is associated with thinner primary melanoma and better outcome, although a …

Epigenetic regulators, when genomically altered, may become driver oncogenes that
mediate otherwise unexplained pro-oncogenic changes lacking a clear genetic stimulus …

Purpose: Previously identified transcriptomic signatures have been based on primary and
metastatic melanomas with relatively few American Joint Committee on Cancer (AJCC) …

The male reproductive system relies heavily on the prostate gland for optimal fertility. One of
its key responsibilities is to produce a fluid that constitutes approximately 30% of the total …

Purpose Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype that
disproportionately affects women of African ancestry (WAA) and is often associated with …

Microscopic ulceration is an independent predictor of melanoma death. Here, we used
systems biology to query the role of host and tumour‐specific processes in defining the …

Compared to tissue biopsies, ctDNA provides a more comprehensive tumor landscape,
allowing for repeated non-invasive sampling. Therefore, ctDNA detection has a broad …

Introduction 1, 25-dihydroxyvitamin D3 is the ligand for the dimeric vitamin D receptor (VDR)
and retinoid X receptor (RXR): ligand-receptor binding facilitates transcription of target …