[HTML][HTML] Naturally occurring hepatitis B virus reverse transcriptase mutations related to potential antiviral drug resistance and liver disease progression
The annual number of deaths caused by hepatitis B virus (HBV)-related disease, including
cirrhosis and hepatocellular carcinoma (HCC), is estimated as 887000. The reported …
cirrhosis and hepatocellular carcinoma (HCC), is estimated as 887000. The reported …
[HTML][HTML] Quasispecies structure, cornerstone of hepatitis B virus infection: mass sequencing approach
Hepatitis B virus (HBV) is a DNA virus with complex replication, and high replication and
mutation rates, leading to a heterogeneous viral population. The population is comprised of …
mutation rates, leading to a heterogeneous viral population. The population is comprised of …
Potential resistant mutations within HBV reverse transcriptase sequences in nucleos (t) ide analogues-experienced patients with hepatitis B virus infection
X Zhang, X Chen, M Wei, C Zhang, T Xu, L Liu, Z Xu - Scientific reports, 2019 - nature.com
This study was performed to analyze the potential resistant mutations within HBV reverse
transcriptase (RT) sequences against nucleos (t) ide analogues (NA). HBV DNA RT region …
transcriptase (RT) sequences against nucleos (t) ide analogues (NA). HBV DNA RT region …
Hepatitis B virus mutation pattern rtL180M+ A181C+ M204V may contribute to entecavir resistance in clinical practice
Y Liu, Y Zhou, X Li, M Niu, R Chen, J Shao… - Emerging microbes & …, 2019 - Taylor & Francis
ABSTRACT Background and Aims: Entecavir (ETV) resistance of hepatitis B virus (HBV)
conventionally requires rt184, 202, or 250 mutations plus lamivudine-resistance mutation …
conventionally requires rt184, 202, or 250 mutations plus lamivudine-resistance mutation …
Profile of mutations in the reverse transcriptase and overlap** surface genes of hepatitis B virus (HBV) in treatment-naïve Indonesian HBV carriers
LN Yamani, Y Yano, T Utsumi… - Japanese journal of …, 2017 - jstage.jst.go.jp
Mutations in the reverse transcriptase (RT) region of the hepatitis B virus (HBV) genome are
an important factor in low therapeutic effectiveness. Nonetheless, the prevalence of these …
an important factor in low therapeutic effectiveness. Nonetheless, the prevalence of these …
Next-generation sequencing for the diagnosis of hepatitis B: current status and future prospects
S Garcia-Garcia, MF Cortese… - Expert Review of …, 2021 - Taylor & Francis
ABSTRACT Introduction Hepatitis B virus (HBV) causes a complex and persistent infection
with a major impact on patients health. Viral-genome sequencing can provide valuable …
with a major impact on patients health. Viral-genome sequencing can provide valuable …
Evaluation of genotype characteristics and drug resistance mutations in patients with chronic hepatitis B
C He, X Wu, Z You, T Zhou, L Diao, Y Yang, L Wu… - Scientific Reports, 2024 - nature.com
Hepatitis B is one of the public health priorities worldwide, especially in the Southwest
China. Our study aimed to investigate the relationship between genotypes and drug …
China. Our study aimed to investigate the relationship between genotypes and drug …
Mutational characterization of HBV reverse transcriptase gene and the genotype-phenotype correlation of antiviral resistance among Chinese chronic hepatitis B …
Y Fu, S Wu, Y Hu, T Chen, Y Zeng, C Liu… - Emerging Microbes & …, 2020 - Taylor & Francis
ABSTRACT Background and Aims: The drug resistance of hepatitis B virus (HBV) originates
from mutations within HBV reverse transcriptase (RT) region during the prolonged antiviral …
from mutations within HBV reverse transcriptase (RT) region during the prolonged antiviral …
Evolution of drug-resistant mutations in HBV genomes in patients with treatment failure during the past seven years (2010–2016)
H Zhang, L Liu, C Ye, C Chen, S Hang, Z Zhu, H Shen… - Virus Genes, 2018 - Springer
The objective of this study was to analyze the prevalence of drug-resistant HBV mutants in
patients with treatment failure during the past seven years (2010–2016). 4055 HBV-infected …
patients with treatment failure during the past seven years (2010–2016). 4055 HBV-infected …
Core promoter mutation of nucleotides A1762T and G1764A of hepatitis B virus increases core promoter transactivation by hepatocyte nuclear factor 1
MS Seong, HJ Hwang, EA Jang, JA Jang… - Journal of …, 2022 - Springer
Hepatitis B virus (HBV) infection highly increases the risk for liver cirrhosis and
hepatocellular carcinoma (HCC). The clinical manifestation of HBV infection is determined …
hepatocellular carcinoma (HCC). The clinical manifestation of HBV infection is determined …