The diverse roles of DNA methylation in mammalian development and disease
DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …
methylation has numerous functions: it is implicated in the repression of transposons and …
DNA methylation: roles in mammalian development
ZD Smith, A Meissner - Nature Reviews Genetics, 2013 - nature.com
DNA methylation is among the best studied epigenetic modifications and is essential to
mammalian development. Although the methylation status of most CpG dinucleotides in the …
mammalian development. Although the methylation status of most CpG dinucleotides in the …
SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age
L1 retrotransposons are an abundant class of transposable elements that pose a threat to
genome stability and may have a role in age-related pathologies such as cancer. Recent …
genome stability and may have a role in age-related pathologies such as cancer. Recent …
Contribution of intragenic DNA methylation in mouse gametic DNA methylomes to establish oocyte-specific heritable marks
H Kobayashi, T Sakurai, M Imai, N Takahashi… - PLoS …, 2012 - journals.plos.org
Genome-wide dynamic changes in DNA methylation are indispensable for germline
development and genomic imprinting in mammals. Here, we report single-base resolution …
development and genomic imprinting in mammals. Here, we report single-base resolution …
De novo DNA methylation: a germ cell perspective
DNA methylation is a fundamentally important epigenetic modification of the mammalian
genome that has widespread influences on gene expression. During germ-cell specification …
genome that has widespread influences on gene expression. During germ-cell specification …
De novo DNA methylation drives 5hmC accumulation in mouse zygotes
R Amouroux, B Nashun, K Shirane, S Nakagawa… - Nature cell …, 2016 - nature.com
Zygotic epigenetic reprogramming entails genome-wide DNA demethylation that is
accompanied by Tet methylcytosine dioxygenase 3 (Tet3)-driven oxidation of 5 …
accompanied by Tet methylcytosine dioxygenase 3 (Tet3)-driven oxidation of 5 …
Mouse oocyte methylomes at base resolution reveal genome-wide accumulation of non-CpG methylation and role of DNA methyltransferases
DNA methylation is an epigenetic modification that plays a crucial role in normal mammalian
development, retrotransposon silencing, and cellular reprogramming. Although methylation …
development, retrotransposon silencing, and cellular reprogramming. Although methylation …
High-resolution DNA methylome analysis of primordial germ cells identifies gender-specific reprogramming in mice
Dynamic epigenetic reprogramming occurs during mammalian germ cell development,
although the targets of this process, including DNA demethylation and de novo methylation …
although the targets of this process, including DNA demethylation and de novo methylation …
Establishment of paternal methylation imprint at the H19/Igf2 imprinting control region
J Liao, S Song, S Gusscott, Z Fu, I VanderKolk… - Science …, 2023 - science.org
The insulator model explains the workings of the H19 and Igf2 imprinted domain in the
soma, where insulation of the Igf2 promoter from its enhancers occurs by CTCF in the …
soma, where insulation of the Igf2 promoter from its enhancers occurs by CTCF in the …
[HTML][HTML] Rebooting the epigenomes during mammalian early embryogenesis
Upon fertilization, terminally differentiated gametes are transformed to a totipotent zygote,
which gives rise to an embryo. How parental epigenetic memories are inherited and …
which gives rise to an embryo. How parental epigenetic memories are inherited and …