Autophagy and senescence in cancer therapy

DA Gewirtz - Journal of cellular physiology, 2014 - Wiley Online Library
Autophagy and senescence have multiple and often overlap** and complementary
functions in cancer, both in terms of influencing tumor development and in modulating the …

COVID-19, ferrosenescence and neurodegeneration, a mini-review

A Sfera, C Osorio, G Maguire, L Rahman… - Progress in Neuro …, 2021 - Elsevier
Exacerbation of cognitive, motor and nonmotor symptoms have been described in critically
ill COVID-19 patients, indicating that, like prior pandemics, neurodegenerative sequelae …

Sesamol alleviates sarcopenia via activating AKT/mTOR/FoxO1 signal pathway in aged obese mice

J Yang, Z Wang, Y **e, Y Tang, Y Fu, Z Xu… - Plant Foods for Human …, 2024 - Springer
Sesamol is a major bioactive component extracted from sesame seeds and has various
medicinal properties. However, the effects of sesamol on sarcopenia associated with aging …

Mitigation of radiation-induced jejunum injuries in rats through modulation of the p53-miR34a axis using etoricoxib-loaded nanostructured lipid carriers

NS Hamed, S Khateeb, SA Elfouly, AMA Tolba… - Scientific Reports, 2024 - nature.com
The most widely used cancer therapy is radiation therapy, but radiation damage to healthy
tissues, particularly the gastrointestinal (GI) system, frequently reduces its effectiveness. This …

Mitochondria in cell senescence: A Friend or Foe?

Q Chen, L Young, R Barsotti - … in Protein Chemistry and Structural Biology, 2023 - Elsevier
Cell senescence denotes cell growth arrest in response to continuous replication or stresses
damaging DNA or mitochondria. Mounting research suggests that cell senescence attributes …

Lithium inhibits oxidative stress-induced neuronal senescence through miR-34a

KU Tufekci, B Alural, E Tarakcioglu, T San… - Molecular biology …, 2021 - Springer
Neuronal senescence, triggered by telomere shortening, oncogene activation, DNA
damage, or oxidative stress, has been associated with neurodegenerative diseases' …

Antiproliferative and apoptogenic effects of Cassia fistula L. n-hexane fraction against human cervical cancer (HeLa) cells

S Kaur, K Pandit, M Chandel, S Kaur - Environmental Science and …, 2020 - Springer
The current study was performed to evaluate the antiproliferative and apoptosis-inducing
potential of n-hexane fraction from Cassia fistula L.(Caesalpinioideae) fruits. The …

Identification of a new human senescent skin cell marker ribonucleoside-diphosphate reductase subunit M2 B

K Takaya, K Kishi - Biogerontology, 2024 - Springer
In skin aging, it has been hypothesized that aging fibroblasts accumulate within the
epidermal basal layer, dermis, and subcutaneous fat, causing abnormal tissue remodeling …

Oncogene-induced senescence in meningiomas—an immunohistochemical study

V Mijajlović, M Miler, R Ilić, D Rašić… - Journal of Neuro …, 2024 - Springer
Purpose Meningiomas are tumours originating from meningothelial cells, the majority
belonging to grade 1 according to the World Health Organization classification of the …

Senolytics and Their Effects on Various Diseases

KD Oruç, AG Mutlu - Turkish Journal of Health Science and Life, 2024 - dergipark.org.tr
Senescence is the result of a process that is physiological for cells. With aging, there is an
increase in the number of senescent cells in organisms, and these cells produce a number …