Spike timing dependent plasticity (STDP) is a phenomenon in which the precise timing of
spikes affects the sign and magnitude of changes in synaptic strength. STDP is often …

Plasticity at excitatory glutamatergic synapses in the central nervous system is believed to
be critical for neuronal circuits to process and encode information, allowing animals to …

INTRODUCTION Neuromodulators, such as dopamine, norepinephrine, or serotonin, exert
powerful control over neural circuit dynamics that give rise to diverse neural function and …

Microtubule-associated protein 2 (MAP2) is the predominant cytoskeletal regulator within
neuronal dendrites, abundant and specific enough to serve as a robust somatodendritic …

Focal adhesions undergo myosin-II-mediated maturation wherein they grow and change
composition to modulate integrin signalling for cell migration, growth and differentiation. To …

Autophagy is a conserved, catabolic process essential for maintaining cellular homeostasis.
Malfunctional autophagy contributes to neurodevelopmental and neurodegenerative …

Abstract The Rho GTPase proteins Rac1, RhoA and Cdc42 have a central role in regulating
the actin cytoskeleton in dendritic spines, thereby exerting control over the structural and …

Memory formation is believed to result from changes in synapse strength and structure.
While memories may persist for the lifetime of an organism, the proteins and lipids that make …

Enlargement of dendritic spines and synapses correlates with enhanced synaptic strength
during long‐term potentiation (LTP), especially in immature hippocampal neurons. Less …

Leucine-rich repeat kinase 2 (LRRK2) is enriched in the striatal projection neurons (SPNs).
We found that LRRK2 negatively regulates protein kinase A (PKA) activity in the SPNs …