Differential gene expression mechanisms ensure cellular differentiation and plasticity to
shape ontogenetic and phylogenetic diversity of cell types. A key regulator of differential …

Methylation of arginine residues by protein arginine methyltransferases (PRMTs) is involved
in the regulation of fundamental cellular processes, including transcription, RNA processing …

Nuclear receptors (NRs) are a family of transcription factors that regulate numerous
physiological processes such as metabolism, reproduction, inflammation, as well as the …

Numerous substrates have been identified for Type I and II arginine methyltransferases
(PRMTs). However, the full substrate spectrum of the only type III PRMT, PRMT7, and its …

Simple Summary The CREB-binding protein (CBP) and p300 are paralogous lysine
acetyltransferases that serve as critical co-activators for transcription factors involved in …

The activities of 1α, 25-dihydroxyvitamin D3, 1, 25D3, are mediated via its binding to the
vitamin D receptor (VDR), a ligand-dependent transcription factor that belongs to the nuclear …

Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine
methyltransferase that posttranslationally modifies proteins that regulate multiple levels of …

The estrogen receptor alpha (ERα) is a steroid receptor that is pivotal in the initiation and
progression of most breast cancers. ERα regulates gene transcription through recruitment of …

Steroid receptors activate gene transcription by recruiting coactivators to initiate transcription
of their target genes. For most nuclear receptors, the ligand-dependent activation function …

Simple Summary Breast cancer is the most common cancer in women, affecting 1 in 20
women globally. Breast cancer is divided into four subtypes: luminal A, luminal B, HER2 …