Molecular determinants of BK channel functional diversity and functioning
Large-conductance Ca2+-and voltage-activated K+ (BK) channels play many physiological
roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion …
roles ranging from the maintenance of smooth muscle tone to hearing and neurosecretion …
BK channel activation: structural and functional insights
US Lee, J Cui - Trends in neurosciences, 2010 - cell.com
The voltage-and Ca 2+-activated K+(BK) channels are involved in the regulation of
neurotransmitter release and neuronal excitability. Structurally, BK channels are …
neurotransmitter release and neuronal excitability. Structurally, BK channels are …
Molecular mechanisms of BK channel activation
J Cui, H Yang, US Lee - Cellular and Molecular Life Sciences, 2009 - Springer
Large conductance, Ca 2+-activated potassium (BK) channels are widely expressed
throughout the animal kingdom and play important roles in many physiological processes …
throughout the animal kingdom and play important roles in many physiological processes …
Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy
L Wang, FJ Sigworth - Nature, 2009 - nature.com
A long-sought goal in structural biology has been the imaging of membrane proteins in their
membrane environments. This goal has been achieved with electron crystallography in …
membrane environments. This goal has been achieved with electron crystallography in …
Modulation of BK channel function by auxiliary beta and gamma subunits
Q Li, J Yan - International review of neurobiology, 2016 - Elsevier
Abstract The large-conductance, Ca 2+-and voltage-activated K+(BK) channel is
ubiquitously expressed in mammalian tissues and displays diverse biophysical or …
ubiquitously expressed in mammalian tissues and displays diverse biophysical or …
Regulation of Voltage-Activated K+ Channel Gating by Transmembrane β Subunits
X Sun, MA Zaydman, J Cui - Frontiers in pharmacology, 2012 - frontiersin.org
Voltage-activated K+ (KV) channels are important for sha** action potentials and
maintaining resting membrane potential in excitable cells. KV channels contain a central …
maintaining resting membrane potential in excitable cells. KV channels contain a central …
Two classes of regulatory subunits coassemble in the same BK channel and independently regulate gating
High resolution proteomics increasingly reveals that most native ion channels are
assembled in macromolecular complexes. However, whether different partners have …
assembled in macromolecular complexes. However, whether different partners have …
Structural determinants of phosphatidylinositol 4, 5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site
Big or high conductance potassium (BK) channels are activated by voltage and intracellular
calcium (Ca 2+). Phosphatidylinositol 4, 5-bisphosphate (PIP 2), a ubiquitous modulator of …
calcium (Ca 2+). Phosphatidylinositol 4, 5-bisphosphate (PIP 2), a ubiquitous modulator of …
[HTML][HTML] The mechanism of Ca2+-independent activation of BKCa channels in mouse inner hair cells and the crucial role of the BK channels in auditory perception
ZS Shen, J Gan, B Xu, YL Chen, FF Zhang, JW Ji… - Journal of Biological …, 2025 - Elsevier
BK channels are expressed in mouse cochlear inner hair cells (IHCs) and exhibit Ca 2+-
independent activation at negative potentials. However, the mechanism underlying Ca 2+ …
independent activation at negative potentials. However, the mechanism underlying Ca 2+ …
A charged residue in S4 regulates coupling among the activation gate, voltage, and Ca2+ sensors in BK channels
Coupling between the activation gate and sensors of physiological stimuli during ion
channel activation is an important, but not well-understood, molecular process. One difficulty …
channel activation is an important, but not well-understood, molecular process. One difficulty …