β2-adrenoceptor agonists are the first-line treatment of asthma and chronic obstructive
pulmonary disease (COPD), in which a short-acting β2-adrenoceptor agonist is used as …

In inflammatory diseases such as Crohn's disease (CD) and ulcerative colitis (UC), one
would expect that TNF or IL-6 stimulates the hypothalamus, which activates the …

Yohimbine, an α2 adrenoreceptor antagonist, enhances norepinephrine (NE) release and
increases sympathetic activity. We examined the behavioral, peripheral sympathetic and …

It is believed that an inflammation‐induced activation of the CNS leads to an inhibition of
overshooting immune responses to prevent extensive local cytokine secretion. However …

This article focuses on the respiratory epithelium and airway smooth muscle homeostasis.
Asthma and related respiratory conditions are characterized by a profound increase in the …

1 Long‐term treatment with β2‐adrenoceptor agonists can lead to a decreased therapeutic
efficacy of bronchodilatation in patients with obstructive pulmonary disease. In order to …

Summary 1 There has been considerable debate whether responses mediated via β1‐and
β2‐adrenoceptors (β1ARs and β2ARs) display the same degree of desensitization after …

Bronchial hyperresponsiveness to physical, chemical, and pharmacological stimuli is a
common characteristic of patients with asthma and chronic obstructive pulmonary disease …

In rabbit aortic strip preparations, angiotensin II (AII) concentration-contractile response
curves (0.3–100 nM) were highly reproducible. However, tachyphylaxis to the contractile …

In vitro desensitization of β 2-adrenoceptor-mediated relaxation of guinea-pig isolated
parenchymal strips was examined. Concentration-response curves for isoprenaline were …