[HTML][HTML] Clinical pharmacology of atypical antipsychotics: an update
This review will concentrate on the clinical pharmacology, in particular pharmacodynamic
data, related to atypical antipsychotics, clozapine, risperidone, paliperidone, olanzapine …
data, related to atypical antipsychotics, clozapine, risperidone, paliperidone, olanzapine …
Polymorphism of human cytochrome P450 enzymes and its clinical impact
Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …
specific genes affect drug response. This article highlights current pharmacogenetic …
Clinical pharmacokinetics of atypical antipsychotics: an update
MC Mauri, S Paletta, C Di Pace, A Reggiori… - Clinical …, 2018 - Springer
Therapeutic drug monitoring studies have generally concentrated on controlling compliance
and avoiding side effects by maintaining long-term exposure to minimally effective blood …
and avoiding side effects by maintaining long-term exposure to minimally effective blood …
The AGNP-TDM expert group consensus guidelines: therapeutic drug monitoring in psychiatry
Therapeutic Drug Monitoring (TDM) is a valid tool to optimise pharmacotherapy. It enables
the clinician to adjust the dosage of drugs according to the characteristics of the individual …
the clinician to adjust the dosage of drugs according to the characteristics of the individual …
Treatment-resistant schizophrenia: current insights on the pharmacogenomics of antipsychotics
Up to 30% of people with schizophrenia do not respond to two (or more) trials of
dopaminergic antipsychotics. They are said to have treatment-resistant schizophrenia (TRS) …
dopaminergic antipsychotics. They are said to have treatment-resistant schizophrenia (TRS) …
Pharmacogenetics and pharmacogenomics of schizophrenia: a review of last decade of research
The last decade of research into the pharmacogenetics of antipsychotics has seen the
development of genetic tests to determine the patients' metabolic status and the first attempts …
development of genetic tests to determine the patients' metabolic status and the first attempts …
Genetic polymorphism of metabolic enzymes P450 (CYP) as a susceptibility factor for drug response, toxicity, and cancer risk
The polymorphic P450 (CYP) enzyme superfamily is the most important system involved in
the biotransformation of many endogenous and exogenous substances including drugs …
the biotransformation of many endogenous and exogenous substances including drugs …
Clozapine's multiple cellular mechanisms: What do we know after more than fifty years? A systematic review and critical assessment of translational mechanisms …
Almost fifty years after its first introduction into clinical care, clozapine remains the only
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …
evidence-based pharmacological option for treatment-resistant schizophrenia (TRS), which …
Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2
Human CYP1A2 is one of the major CYPs in human liver and metabolizes a number of
clinical drugs (eg, clozapine, tacrine, tizanidine, and theophylline; n> 110), a number of …
clinical drugs (eg, clozapine, tacrine, tizanidine, and theophylline; n> 110), a number of …
CYP2C9 Genotype‐guided Warfarin Prescribing Enhances the Efficacy and Safety of Anticoagulation: A Prospective Randomized Controlled Study
Warfarin anticoagulation effect is characterized by marked variability, some of which has
been attributed to CYP2C9 polymorphisms. This study prospectively examines whether a …
been attributed to CYP2C9 polymorphisms. This study prospectively examines whether a …